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Título: | Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans |
Autor: | Sánchez-Moreno, Concepción CSIC ORCID ; Cano, M. Pilar CSIC ORCID ; Ancos, Begoña de CSIC ORCID ; Plaza, Lucía CSIC ORCID; Olmedilla-Alonso, Begoña CSIC ORCID ; Granado Lorencio, Fernando; Martín, Antonio CSIC ORCID | Palabras clave: | Orange juice Vitamin C Bioavailability F2-isoprostanes Uric acid Food-frequency questionnaire Smoking |
Fecha de publicación: | sep-2003 | Editor: | American Society for Nutrition | Citación: | American Journal of Clinical Nutrition 78(3): 454-460 (2003) | Resumen: | [Background]: Consumption of fruit and vegetables is associated with improved health and a decreased prevalence of chronic degenerative processes. [Objectives]: The objectives were to assess the bioavailability of vitamin C from orange juice and its influence on plasma vitamin C and 8-epi-prostaglandin F2α (8-epi-PGF2α) concentrations in a healthy human population. [Design]: Six men and 6 women consumed 500 mL commercial fresh-squeezed orange juice/d for 14 d, corresponding to an intake of 250 mg ascorbic acid/d. On the first day of the study, the subjects drank the juice in one dose (dose-response study), and on days 2–14 they consumed 250 mL in the morning and 250 mL in the afternoon. Blood was collected every hour for 6 h on the first day and again on days 7 and 14. [Results]: Baseline plasma vitamin C concentrations were significantly higher (P = 0.03) among the women than among the men (56.4 ± 4.4 compared with 44.3 ± 3.5 µmol/L). In the dose-response study, the maximum increase in plasma vitamin C occurred 3 h postdose in both the men and the women. Vitamin C concentrations remained significantly higher on days 7 and 14 than at baseline. Baseline concentrations of 8-epi-PGF2α were significantly higher (P = 0.03) among the men than among the women (249.6 ± 25.4 compared with 177.7 ± 6.2 pg/mL) but decreased significantly (P = 0.04) by day 14 of the intervention. A significant inverse correlation was observed between vitamin C and 8-epi-PGF2α (r = -0.791, P = 0.0022). Among smokers, baseline vitamin C was lower and 8-epi-PGF2α higher than among nonsmokers. [Conclusions]: Drinking orange juice (500 mL/d) increases plasma concentrations of vitamin C and reduces concentrations of 8-epi-PGF2α in humans. These effects were significantly more pronounced in smokers. | Descripción: | 7 páginas, 1 figura, 4 tablas.-- Comunicación presentada al Phytochemical Society of Europe (PSE) Symposium on Dietary Phytochemicals and Human Health, celebrado en Salamanca (España) en Abril de 2002. | Versión del editor: | http://www.ajcn.org/content/78/3/454.full | URI: | http://hdl.handle.net/10261/34607 | ISSN: | 0002-9165 |
Aparece en las colecciones: | (IF) Artículos |
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