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Título: | Spermine and spermidine are cytotoxic towards intestinal cell cultures, but are they a health hazard at concentrations found in foods? |
Autor: | Río Lagar, Beatriz del CSIC ORCID ; Redruello, Begoña CSIC ORCID; Martínez Linares, Daniel; Ladero Losada, Víctor Manuel CSIC ORCID ; Ruas-Madiedo, Patricia CSIC ORCID ; Fernández García, María CSIC ORCID ; Martín, M. Cruz CSIC ORCID ; Álvarez González, Miguel Ángel CSIC ORCID | Palabras clave: | Biogenic amines Cytotoxicity Food safety Spermine Spermidine IC50 NOAEL LOAEL |
Fecha de publicación: | 15-dic-2018 | Editor: | Elsevier | Citación: | Food Chemistry 269: 321-326 (2018) | Resumen: | Spermine and spermidine are polyamines (PA) naturally present in all organisms, in which they have important physiological functions. However, an excess of PA has been associated with health risks. PA accumulates at quite high concentrations in some foods, but a quantitative assessment of the risk they pose has been lacking. In the present work, the cytotoxicity of spermine and spermidine was evaluated using an in vitro human intestinal cell model, and employing real-time cell analysis. Both spermine and spermidine showed a dose-dependent cytotoxic effect towards the cultured cells, with necrosis the mode of action of spermidine and perhaps also that of spermine. Spermine was more cytotoxic than spermidine, but for both PA the concentrations found to be toxic were above the maximum at which they have been found in food. The present results do not, therefore, support the idea that spermine or spermidine in food is harmful to healthy people. | Versión del editor: | http://dx.doi.org/10.1016/j.foodchem.2018.06.148 | URI: | http://hdl.handle.net/10261/186023 | DOI: | 10.1016/j.foodchem.2018.06.148 | ISSN: | 0308-8146 |
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Spermine_spermidine.pdf | 972,77 kB | Adobe PDF | Visualizar/Abrir |
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