|
ID: 81538 - Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
|
493
|
|
ID: 331960 - Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin
|
477
|
|
ID: 62917 - Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin alpha-beta-heterodimers and microtubules
|
477
|
|
ID: 11166 - Fluorescent taxoids as probes of the microtubule cytoskeleton
|
435
|
|
ID: 11061 - Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death
|
434
|
|
ID: 53840 - Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubules
|
416
|
|
ID: 246636 - Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances
|
408
|
|
ID: 53042 - Effects of C7 Substitutions in a High Affinity Microtubule-Binding Taxane on Antitumor Activity and Drug Transport
|
401
|
|
ID: 11133 - Effect of 2′-OH acetylation on the bioactivity and conformation of 7-O-[N-(4′-fluoresceincarbonyl)-l-alanyl]taxol. A NMR-fluorescence microscopy study
|
391
|
|
ID: 59376 - Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel
|
391
|
|
ID: 357143 - Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubulestabilizing activities
|
377
|
|
ID: 344508 - Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation
|
375
|
|
ID: 68967 - Synthesis and Biological Evaluation of Colchicine B‑Ring Analogues Tethered with Halogenated Benzyl Moieties
|
371
|
|
ID: 332684 - Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
|
366
|
|
ID: 77855 - Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity
|
365
|
|
ID: 66233 - The Total Synthesis and Biological Properties of the Cytotoxic Macrolide FD-891 and Its Non-Natural (Z)-C12 Isomer
|
363
|
|
ID: 63849 - Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel Site
|
351
|
|
ID: 53640 - Mechanism of Action of Cytotoxic Macrolides Amphidinolide X and J.
|
342
|
|
ID: 76691 - Immune activation and psychoneurogenic stress modulate corticosterone-releasing effects of lymphokines and ACTH
|
341
|
|
ID: 347483 - High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
|
322
|
|
ID: 4189 - Método de detección y evaluación de compuestos miméticos de paclitaxel
|
311
|
|
ID: 309745 - Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action
|
307
|
|
ID: 69726 - Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
|
302
|
|
ID: 77612 - Corticosterone-releasing activity of immune mediators
|
296
|
|
ID: 78804 - Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface
|
296
|
|
ID: 65812 - Recurrent infectious diseases in human CD53 deficiency
|
283
|
|
ID: 53643 - Highly Stereoselective Total Synthesis of (+)-9-epi-Dictyostatin and (–)-12,13-bis-epi-Dictyostatin Eur. J
|
276
|
|
ID: 43003 - Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.
|
269
|
|
ID: 63392 - Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2', 3', 4'-trimethoxyphenyl)-2, 4, 6- cycloheptatrien-1-one: Protection by bcl-2 and bcl-x (L) and cell cycle arrest
|
264
|
|
ID: 343477 - Fast kinetics of Taxol binding to microtubules:effects of solution variables and microtubule-associated proteins
|
258
|
|
ID: 377007 - Structural basis of colchicine-site targeting acylhydrazones active against multidrug-resistant acute lymphoblastic leukemia
|
213
|
|
ID: 357910 - Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate
|
207
|
|
ID: 433518 - Estudio microbiológico de esferoplastos de Pseudomonas patógenas producidos por antibiosis a nivel de pared y membrana
|
203
|
|
ID: 384540 - Structural model for differential cap maturation at growing microtubule ends
|
195
|
|
ID: 433732 - Mecanismo de accion de los macrolidos citotoxicos amphinolidas X y J
|
138
|
|
ID: 432926 - Aggregated compound biological signatures facilitate phenotypic drug discovery and target elucidation
|
97
|
|
ID: 433730 - La supresión de la respuesta inmune y su significado biológico
|
89
|
|
ID: 433103 - The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin
|
79
|
|
ID: 433415 - Immunosuppressive Effects of Some Organic Compounds with Anti-Inflammatory Activity
|
78
|
|
ID: 433155 - Fluorescent taxoid probes for microtubule research
|
75
|
|
ID: 433106 - Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin
|
73
|
|
ID: 432871 - Chloroacetylation of cyclostreptin influences its interaction with tubulin
|
66
|
|
ID: 432875 - Estudio inmunobiológico de endotoxinas bacterianas
|
66
|
|
ID: 432921 - Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells
|
65
|
|
ID: 433355 - A monoclonal antibody that detects a specific human neutrophil antigen involved in phorbol myristate acetate- and formyl-methionyl-leucyl- phenylalanine-triggered respiratory burst
|
65
|
|
ID: 433408 - Comparative study of immunobiological activities of Pseudomonas aeruginosa and Brucella melitensis lipopolysaccharides
|
65
|
|
ID: 432940 - Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin
|
64
|
|
ID: 433157 - Synthesis and biological activities of high affinity taxane-based fluorescent probes
|
64
|
|
ID: 433143 - Corrigendum: Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J
|
63
|
|
ID: 433112 - Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ
|
62
|
|
ID: 433153 - Probing the Pore Drug Binding Site of Microtubules with Fluorescent Taxanes: Evidence of Two Binding Poses
|
62
|
|
ID: 433296 - Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action
|
62
|
|
ID: 433133 - Synthesis and Biological Evaluation of α-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity
|
61
|
|
ID: 433759 - Systems biology identifies that Gleevec reverses taxane resistance in solid tumors by selective inhibition of a novel plus Tip microtubule-binding variant
|
60
|
|
ID: 433114 - New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism
|
59
|
|
ID: 433412 - Comparative study of chromogenesis and endotoxin production from pathogenic Pseudomonas aeruginosa strains, isolated from neoplastic process
|
59
|
|
ID: 432932 - Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones
|
58
|
|
ID: 432888 - Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring
|
57
|
|
ID: 433360 - Antibodies against a peptide representative of a conserved region of human IFN-α. Differential effects on the antiviral and antiproliferative effects of IFN
|
57
|
|
ID: 433512 - Aplicación de los anticuerpos monoclonales a la investigación microbiológica
|
57
|
|
ID: 438018 - CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement
|
57
|
|
ID: 433110 - The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones
|
56
|
|
ID: 433193 - Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines
|
55
|
|
ID: 433509 - Activación linfocitaria en presencia de inhibidores de prostaglandín-sintetasa
|
55
|
|
ID: 432865 - Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting site
|
54
|
|
ID: 432920 - Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin
|
54
|
|
ID: 433145 - Synthesis and Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins
|
53
|
|
ID: 433735 - Modulación de la respuesta inmune por distintas moléculas esteroides
|
53
|
|
ID: 432900 - Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
|
52
|
|
ID: 433752 - Respuesta inmunológica contra bacterias
|
52
|
|
ID: 433132 - Synthesis and biological evaluation as microtubule-active agents of several tetrahydrofuran and spiroacetal derivatives
|
51
|
|
ID: 433347 - Comparative effects of taxol and taxotere on two different human carcinoma lines.
|
51
|
|
ID: 433775 - Zampanolida, un novedoso agente estabilizador de microtubulos quew se une covalentemente al sitio de paclitaxel
|
51
|
|
ID: 433101 - PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors
|
50
|
|
ID: 433108 - Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents
|
50
|
|
ID: 433302 - Structural characterization of a cell wall polysaccharide from Penicillium vermoesenni: Chemotaxonomic application
|
50
|
|
ID: 433399 - Comparative study of endotoxic actions produced by lipopolysaccharide of different gram negative bacteria
|
50
|
|
ID: 433405 - Variación de la actividad inmunosupresora, por modificaciones estructurales en una serie de antiinflamatorios no esteroideos (Esteres de la indometacina)
|
50
|
|
ID: 433725 - "In vivo" depression of either endotoxin or virus induced interferons by rifampicin and rifamycin derivatives
|
50
|
|
ID: 432908 - Anticancer properties of the abietane diterpene 6, 7-dehydroroyleanone obtained by optimized extraction
|
49
|
|
ID: 433299 - An acidic water-soluble cell wall polysaccharide: A chemotaxonomic marker for Fusarium and Gibberella
|
49
|
|
ID: 433365 - Immunoferon (AM3) enhances the activities of early-type interferon inducers and natural killer cells
|
47
|
|
ID: 433516 - Efecto modulador de la isoprinosina, dexametasona e indometacina sobre la reacción mixta de linfocitos y la respuesta citotóxica mediada por células
|
47
|
|
ID: 425092 - Análisis de endotoxinas extraídas de distintas bacterias patógenas mediante espectroscopía infrarroja
|
46
|
|
ID: 432935 - Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin
|
46
|
|
ID: 433513 - Comparative study of inmunobiological activities of Pseudomonas aeruginosa and Brucella melitensis Lipopolysaccharides
|
46
|
|
ID: 433747 - Protein-ligand complex for structure-based design: impact on the affinity and antitumor activity of new tubulin ligands
|
46
|
|
ID: 433192 - Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues
|
45
|
|
ID: 433364 - Sodium diethyldithiocarbamate restores T lymphocyte proliferation, interleukin-2 production and NK activity in cyclophosphamide-immunosuppressed animals
|
45
|
|
ID: 433376 - Enhancement of lymphocyte proliferation, interleukin-2 production and NK activity by inmunoferon (AM-3), a fungal immunomodulator: variations in normal and immunosuppressed mice
|
45
|
|
ID: 433307 - Galactomannans from the cell walls of species of Paecilomyces sect. Paecilomyces and their teleomorphs as immunotaxonomic markers
|
44
|
|
ID: 433336 - An antigenic water-soluble glucogalactomannan extracted from cell walls of Paecilomyces fumosoroseus and Paecilomyces farinosus
|
44
|
|
ID: 433396 - Immunopharmacological controls of indirect side-effects in antibiotherapy (author's transl)
|
44
|
|
ID: 433295 - Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4
|
43
|
|
ID: 433341 - Transient inhibition of capacitative calcium entry in human neutrophils by a monoclonal antibody directed against a 19-kDa antigen
|
43
|
|
ID: 433197 - Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: Modification of the side chain
|
42
|
|
ID: 433319 - Identification of β(III) and β(IV)-tubulin isotypes in cold-adapted microtubules from Atlantic cod (Gadus morhua): Antibody mapping and cDNA sequencing
|
42
|
|
ID: 433401 - 'In vivo' effects of acetylsalicylic acid and two ether derived compounds on primary immune response and lymphoblastic transformation
|
42
|
|
ID: 433510 - Antibody diversity and idiotypes: primary structural analysis of monoclonal A/J antiarsonate antibodies
|
42
|
|
ID: 433768 - Targeting bacterial cell division protein FtsZ with small molecules and fluorescent probes
|
42
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