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Title

Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues

AuthorsWang, Lei; Alcaraz, Ana A.; Matesanz, Ruth CSIC ; Yang, Chun-Gang; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Li, Ye-Zhi; Snyder, James P.; Fang, Wei-shuo S.
KeywordsBinding conformation
Paclitaxel
SAR studies
Taxol analogues
Issue Date1-Jun-2007
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 17(11): 3191- 3194 (2007)
AbstractIn combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with β-tubulin.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2007.03.026
URIhttp://hdl.handle.net/10261/251539
Identifiersdoi: 10.1016/j.bmcl.2007.03.026
issn: 0960-894X
Appears in Collections:(CIB) Artículos

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