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Title: | Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues |
Authors: | Wang, Lei; Alcaraz, Ana A.; Matesanz, Ruth CSIC ; Yang, Chun-Gang; Barasoain, Isabel CSIC ; Díaz, José Fernando CSIC ORCID ; Li, Ye-Zhi; Snyder, James P.; Fang, Wei-shuo S. | Keywords: | Binding conformation Paclitaxel SAR studies Taxol analogues |
Issue Date: | 1-Jun-2007 | Publisher: | Elsevier | Citation: | Bioorganic and Medicinal Chemistry Letters 17(11): 3191- 3194 (2007) | Abstract: | In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with β-tubulin. | Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2007.03.026 | URI: | http://hdl.handle.net/10261/251539 | Identifiers: | doi: 10.1016/j.bmcl.2007.03.026 issn: 0960-894X |
Appears in Collections: | (CIB) Artículos |
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