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Título: | Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubules |
Autor: | Marco, J. Alberto; García-Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara CSIC; Notararigo, Sara CSIC ORCID; Díaz, José Fernando CSIC ORCID ; Barasoain, Isabel CSIC | Palabras clave: | Tubulin Tubulin-active compound Microtubule destabilization Pironetin analogue Cytotoxicity |
Fecha de publicación: | may-2011 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry 46(5):1630-1637(2011) | Resumen: | The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities | Descripción: | 8 páginas, 4 figuras, 1 tabla, 2 esquemas -- PAGS nros. 1630-1637 | Versión del editor: | http://dx.doi.org/10.1016/j.ejmech.2011.02.011 | URI: | http://hdl.handle.net/10261/51844 | DOI: | 10.1016/j.ejmech.2011.02.011 | ISSN: | 0223-5234 | E-ISSN: | 1768-3254 |
Aparece en las colecciones: | (CIB) Artículos |
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