Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting site

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Título:	Shotgun and targeted MS analyses pinpoint the zampanolide-tubulin interacting site
Autor:	Calvo, Enrique; Field, Jessica J.; Pera, Benet CSIC; Zuwerra, D.; López, Juan Antonio; Camafeita, Emilio; Barasoain, Isabel CSIC ; Altmann, Karl-Heinz; Díaz, José Fernando CSIC ORCID
Fecha de publicación:	2011
Editor:	Sociedad Española de Proteómica
Citación:	Proteómica: revista de la Sociedad Española de Proteómica 7: 163-163 (2011)
Resumen:	Microtubule Stabilizing Agents (MSA) are one of the most successful antitumour drugs used in clinical treatment of neoplasic diseases. These compounds mimic the paclitaxel mechanism of action, which preferentially binds to microtubules the assembled form of tubulin, displacing the assembly equilibrium between dimeric and polymeric tubulin. Since this assembly and disassembly equilibrium is essential to cell division, compounds that bind tubulin target rapidly dividing cells (as tumoural ones), arresting them in mitosis, and finally killing them through apoptosis.
Descripción:	Resumen del trabajo presentado en el 4th Congress of the Spanish Proteomics Society: “New Trends in Proteomics”, celebrado en Segovia (España), del 8 al 11 de febrero de 2011
Versión del editor:	http://hdl.handle.net/10396/10431
URI:	http://hdl.handle.net/10261/251214
ISSN:	1888-0096
Aparece en las colecciones:	(CIB) Artículos