Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/220005
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Bioavailability of melatonin from lentil sprouts and Its role in the plasmatic antioxidant status in rats |
Autor: | Rebollo-Hernanz, Miguel CSIC ORCID ; Aguilera, Yolanda CSIC ORCID ; Herrera, Teresa CSIC ; Tábata Cayuelas, L.; Dueñas, Montserrat CSIC ORCID; Rodríguez-Rodríguez, Pilar; Ramiro-Cortijo, David; Arribas, Silvia M.; Martín-Cabrejas, María A. CSIC ORCID | Palabras clave: | Melatonin Phenolc compounds Bioavailability Lentil sprouts |
Fecha de publicación: | 2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Foods 9(3): 330 (2020) | Resumen: | Melatonin is a multifunctional antioxidant neurohormone found in plant foods such as lentil sprouts. We aim to evaluate the effect of lentil sprout intake on the plasmatic levels of melatonin and metabolically related compounds (plasmatic serotonin and urinary 6-sulfatoxymelatonin), total phenolic compounds, and plasmatic antioxidant status, and compare it with synthetic melatonin. The germination of lentils increases the content of melatonin. However, the phenolic content diminished due to the loss of phenolic acids and flavan-3-ols. The flavonol content remained unaltered, being the main phenolic family in lentil sprouts, primarily composed of kaempferol glycosides. Sprague Dawley rats were used to investigate the pharmacokinetic profile of melatonin after oral administration of a lentil sprout extract and to evaluate plasma and urine melatonin and related biomarkers and antioxidant capacity. Melatonin showed maximum concentration (45.4 pg/mL) 90 min after lentil sprout administration. The plasmatic melatonin levels increased after lentil sprout intake (70%, p < 0.05) with respect to the control, 1.2-fold more than after synthetic melatonin ingestion. These increments correlated with urinary 6-sulfatoxymelatonin content (p < 0.05), a key biomarker of plasmatic melatonin. Nonetheless, the phenolic compound content did not exhibit any significant variation. Plasmatic antioxidant status increased in the antioxidant capacity upon both lentil sprout and synthetic melatonin administration. For the first time, we investigated the bioavailability of melatonin from lentil sprouts and its role in plasmatic antioxidant status. We concluded that their intake could increase melatonin plasmatic concentration and attenuate plasmatic oxidative stress. | Descripción: | This article belongs to the Special Issue Advances in Production, Properties and Applications of Sprouted Seeds. | Versión del editor: | https://doi.org/10.3390/foods9030330 | URI: | http://hdl.handle.net/10261/220005 | DOI: | 10.3390/foods9030330 | E-ISSN: | 2304-8158 |
Aparece en las colecciones: | (CIAL) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Bioavailarats.pdf | 1,57 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 21-abr-2024
SCOPUSTM
Citations
21
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 25-feb-2024
Page view(s)
133
checked on 01-may-2024
Download(s)
227
checked on 01-may-2024