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http://hdl.handle.net/10261/170831
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dc.contributor.author | Molinar-Toribio, Eunice | - |
dc.contributor.author | Fuguet, Elisabet | - |
dc.contributor.author | Ramos-Romero, Sara | - |
dc.contributor.author | Taltavull, Núria | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Nogués, M. R. | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Pérez-Jiménez, Jara | - |
dc.date.accessioned | 2018-10-09T11:55:17Z | - |
dc.date.available | 2018-10-09T11:55:17Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1007/s00394-016-1323-9 | - |
dc.identifier | e-issn: 1436-6215 | - |
dc.identifier | issn: 1436-6207 | - |
dc.identifier.citation | European Journal of Nutrition 57(1): 339-349 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/170831 | - |
dc.description.abstract | [Purpose]: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). [Methods]: Adult female Wistar–Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC–MS/MS analysis. [Results]: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. [Conclusions]: These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes. | - |
dc.description.sponsorship | This research was supported by the Spanish Ministry of Science and Innovation (Grants: AGL2009-12374-C03-01, -02 and -03; and AGL2013-49079-C2-1, 2 and -R, and through a doctoral fellowship to L.M.). The Panamanian Government (SENACYT/IFARHU) awarded a graduate fellowship to E.M.-T. The ISCIII is acknowledged for a “Sara Borrell” postdoctoral contract to J.P.-J. (CD09/00068). | - |
dc.publisher | Springer Nature | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-49079-C2-1-R | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | - |
dc.subject | Metabolites | - |
dc.subject | Bioavailability | - |
dc.subject | High-fat high-sucrose diet | - |
dc.subject | Proanthocyanidins | - |
dc.subject | Polyphenols | - |
dc.title | A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s00394-016-1323-9 | - |
dc.relation.publisherversion | https://doi.org/10.1007/s00394-016-1323-9 | - |
dc.date.updated | 2018-10-09T11:55:18Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Secretaría Nacional de Ciencia y Tecnología (Panamá) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.pmid | 27730364 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
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