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Título: | Metabolic fate and cardiometabolic effects of phenolic compounds from red-fleshed apple in hypercholesterolemic rats: A comparative study with common white-fleshed apple. The AppleCOR Study |
Autor: | Yuste, Silvia CSIC ORCID; Ludwig, Iziar A.; Romero, María Paz; Piñol-Felis, Carme; Catalán, Úrsula; Pedret, Anna; Valls, Rosa-Maria; Fernández-Castillejo, Sara; Motilva, María-José CSIC ORCID ; Macià, Alba; Rubió, Laura | Palabras clave: | Anthocyanins Aortic thickness Bowman’s space Phenolic compounds Red-fleshed apple Rustained intake UPLC-MS/MS |
Fecha de publicación: | may-2021 | Editor: | John Wiley & Sons | Citación: | Molecular Nutrition and Food Research 65(10): 2001225 (2021) | Resumen: | The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R andHFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect sobserved after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R andHFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats. | Versión del editor: | http://dx.doi.org/10.1002/mnfr.202001225 | URI: | http://hdl.handle.net/10261/262037 | DOI: | 10.1002/mnfr.202001225 | Identificadores: | doi: 10.1002/mnfr.202001225 e-issn: 1613-4133 issn: 1613-4125 |
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