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http://hdl.handle.net/10261/215718
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Ivorra-Martinez, Juan | - |
dc.contributor.author | Quiles-Carrillo, Luis | - |
dc.contributor.author | Boronat, Teodomiro | - |
dc.contributor.author | Torres-Giner, Sergio | - |
dc.contributor.author | Covas, José A. | - |
dc.date.accessioned | 2020-06-30T16:45:33Z | - |
dc.date.available | 2020-06-30T16:45:33Z | - |
dc.date.issued | 2020-06-21 | - |
dc.identifier.citation | Polymers 12(6): 1389 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/215718 | - |
dc.description | © 2020 by the authors. | - |
dc.description.abstract | In the present study, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] was reinforced with hydroxyapatite nanoparticles (nHA) to produce novel nanocomposites for potential uses in bone reconstruction. Contents of nHA in the 2.5–20 wt % range were incorporated into P(3HB-co-3HHx) by melt compounding and the resulting pellets were shaped into parts by injection molding. The addition of nHA improved the mechanical strength and the thermomechanical resistance of the microbial copolyester parts. In particular, the addition of 20 wt % of nHA increased the tensile (Et) and flexural (Ef) moduli by approximately 64% and 61%, respectively. At the highest contents, however, the nanoparticles tended to agglomerate, and the ductility, toughness, and thermal stability of the parts also declined. The P(3HB-co-3HHx) parts filled with nHA contents of up to 10 wt % matched more closely the mechanical properties of the native bone in terms of strength and ductility when compared with metal alloys and other biopolymers used in bone tissue engineering. This fact, in combination with their biocompatibility, enables the development of nanocomposite parts to be applied as low-stress implantable devices that can promote bone reconstruction and be reabsorbed into the human body. | - |
dc.description.sponsorship | This research work was funded by the Spanish Ministry of Science and Innovation (MICI) project numbers RTI2018-097249-B-C21 and MAT2017-84909-C2-2-R and the POLISABIO program with grant number 2019-A02. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097249-B-C21 | - |
dc.relation | RTI2018-097249-B-C21/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-84909-C2-2-R | - |
dc.relation | MAT2017-84909-C2-2-R/AEI/10.13039/501100011033 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | P(3HB-co-3HHx) | - |
dc.subject | nHA | - |
dc.subject | Nanocomposites | - |
dc.subject | Mechanical properties | - |
dc.subject | Bone reconstruction | - |
dc.title | Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/polym12061389 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/polym12061389 | - |
dc.date.updated | 2020-06-30T16:45:34Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.pmid | 32575881 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (IATA) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Assessment_Ivorra_Martinez.pdf | 5,43 MB | Adobe PDF | Visualizar/Abrir |
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