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Título: | A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model |
Autor: | Fernández, Javier; Moreno, F. Javier CSIC ORCID ; Olano, Agustín CSIC ; Clemente, Alfonso CSIC ORCID; Villar, Claudio J.; Lombó, Felipe | Palabras clave: | Gutmicrobiota Galacto-oligosaccharides Prevention Colorectal cáncer Prebiotic |
Fecha de publicación: | 2018 | Editor: | Frontiers Media | Citación: | Frontiers in Microbiology 9: 2004 (2018) | Resumen: | Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model (Rattus norvegicus F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as Bifidobacterium. Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC. | Versión del editor: | https://www.frontiersin.org/articles/10.3389/fmicb.2018.02004/full | URI: | http://hdl.handle.net/10261/178333 | DOI: | 10.3389/fmicb.2018.02004 | Identificadores: | doi: 10.3389/fmicb.2018.02004 issn: 1664-302X |
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