Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/250634
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Changes in fatty acid dietary profile affect the brain–gut axis functions of healthy young adult rats in a sex-dependent manner |
Autor: | Jacenik, Damian; Bagüés, Ana; López-Gómez, Laura; Lopez-Tofiño, Yolanda; Iriondo-DeHond, Amaia CSIC ORCID ; Serra, Cristina; Banovcanová, Laura; Gálvez-Robleño, Carlos; Fichna, Jakub; Castillo, M. Dolores del CSIC ORCID ; Uranga-Ocio, José Antonio; Abalo, Raquel CSIC ORCID | Palabras clave: | Behaviour Brain–gut axis Coconut oil Diet Fatty acids Gastrointestinal motility Primrose oil Sex Soy oil Visceral pain |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Nutrients 13(6): 1864 (2021) | Resumen: | Dietary modifications, including those affecting dietary fat and its fatty acid (FA) composition, may be involved in the development of brain–gut axis disorders, with different manifestations in males and females. Our aim was to evaluate the impact of three purified diets with different FA composition on the brain–gut axis in rats of both sexes. Male and female Wistar rats fed a cereal-based standard diet from weaning were used. At young adult age (2–3 months old), animals were divided into three groups and treated each with a different refined diet for 6 weeks: a control group fed on AIN-93G diet containing 7% soy oil (SOY), and two groups fed on AIN-93G modified diets with 3.5% soy oil replaced by 3.5% coconut oil (COCO) or 3.5% evening primrose oil (EP). Different brain–gut axis parameters were evaluated during 4–6 weeks of dietary intervention. Compared with SOY diet (14% saturated FAs, and 58% polyunsaturated FAs), COCO diet (52.2% saturated FAs and 30% polyunsaturated FAs) produced no changes in brain functions and minor gastrointestinal modifications, whereas EP diet (11.1% saturated FAs and 70.56% polyunsaturated FAs) tended to decrease self-care behavior and colonic propulsion in males, and significantly increased exploratory behavior, accelerated gastrointestinal transit, and decreased cecum and fecal pellet density in females. Changes in FA composition, particularly an increase in ω-6 polyunsaturated FAs, seem to facilitate the development of brain–gut axis alterations in a sex-dependent manner, with a relatively higher risk in females. | Descripción: | This article belongs to the Special Issue Dietary Management of Gastrointestinal Diseases and Disorders. | Versión del editor: | https://doi.org/10.3390/nu13061864 | URI: | http://hdl.handle.net/10261/250634 | DOI: | 10.3390/nu13061864 | E-ISSN: | 2072-6643 |
Aparece en las colecciones: | (CIAL) Artículos (IQM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
chanmann.pdf | 9,78 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
2
checked on 25-abr-2024
SCOPUSTM
Citations
4
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 29-feb-2024
Page view(s)
84
checked on 26-abr-2024
Download(s)
85
checked on 26-abr-2024