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Título: | Inter-individual variability in insulin response after grape pomace supplementation in subjects at high cardiometabolic risk: Role of microbiota and miRNA |
Autor: | Ramos-Romero, Sara CSIC ORCID; Léniz, Asier; Martínez-Maqueda, D. CSIC ORCID; Amézqueta, Susana; Fernández-Quintela, Alfredo; Hereu, Mercè CSIC; Torres, Josep Lluís CSIC ORCID; Portillo, María P.; Pérez-Jiménez, Jara CSIC ORCID | Fecha de publicación: | 2021 | Editor: | Wiley-VCH | Citación: | Molecular Nutrition and Food Research 65(2): 2000113 (2021) | Resumen: | [Scope]: Dietary polyphenols have shown promising effects in mechanistic and preclinical studies on the regulation of cardiometabolic alterations. Nevertheless, clinical trials have provided contradictory results, with high inter-individual variability. This study explores the role of gut microbiota and microRNAs (miRNAs) as factors contributing to the inter-individual variability in polyphenol response. [Methods and Results]: 49 subjects with at least two factors of metabolic syndrome are divided between responders (n = 23) or non-responders (n = 26), depending on the variation rate in fasting insulin after grape pomace supplementation (6 weeks). The populations of selected fecal bacteria are estimated from fecal deoxyribonucleic acid (DNA) by quantitative real-time polymerase chain reaction (qPCR), while the microbial-derived short-chain fatty acids (SCFAs) are measured in fecal samples by gas chromatography. MicroRNAs are analyzed on a representative sample, followed by targeted miRNA analysis. Responder subjects show significantly lower (p < 0.05) Prevotella and Firmicutes levels, and increased (p < 0.05) miR-222 levels. [Conclusion]: After evaluating the selected substrates for Prevotella and target genes of miR-222, these variations suggest that responders are those subjects exhibiting impaired glycaemic control. This study shows that fecal microbiota and miRNA expression may be related to inter-individual variability in clinical trials with polyphenols. |
Versión del editor: | https://doi.org/10.1002/mnfr.202000113 | URI: | http://hdl.handle.net/10261/249820 | DOI: | 10.1002/mnfr.202000113 | E-ISSN: | 1613-4133 |
Aparece en las colecciones: | (ICTAN) Artículos (IQAC) Artículos |
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RAMOS 2021_post-print.pdf | 777,32 kB | Adobe PDF | Visualizar/Abrir |
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