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http://hdl.handle.net/10261/88024
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dc.contributor.author | Martín, M. Ángeles | - |
dc.contributor.author | Ramos, Sonia | - |
dc.contributor.author | Cordero Herrera, Isabel | - |
dc.contributor.author | Bravo, Laura | - |
dc.contributor.author | Goya, Luis | - |
dc.date.accessioned | 2013-12-02T13:07:49Z | - |
dc.date.available | 2013-12-02T13:07:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier | doi: 10.3390/nu5082955 | - |
dc.identifier | issn: 2072-6643 | - |
dc.identifier.citation | Nutrients 5(8): 2955-2968 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/88024 | - |
dc.description.abstract | Diabetes mellitus is associated with reductions in glutathione, supporting the critical role of oxidative stress in its pathogenesis. Antioxidant food components such as flavonoids have a protective role against oxidative stress-induced degenerative and age-related diseases. Flavonoids constitute an important part of the human diet; they can be found in most plant foods, including green tea, grapes or cocoa and possess multiple biological activities. This study investigates the chemo-protective effect of a cocoa phenolic extract (CPE) containing mainly flavonoids against oxidative stress induced by tert-butylhydroperoxide (t-BOOH) on Ins-1E pancreatic beta cells. Cell viability and oxidative status were evaluated. Ins-1E cells treatment with 5–20 μg/mL CPE for 20 h evoked no cell damage and did not alter ROS production. Addition of 50 μM t-BOOH for 2 h increased ROS and carbonyl groups content and decreased reduced glutathione level. Pre-treatment of cells with CPE significantly prevented the t-BOOH-induced ROS and carbonyl groups and returned antioxidant defences to adequate levels. Thus, Ins-1E cells treated with CPE showed a remarkable recovery of cell viability damaged by t-BOOH, indicating that integrity of surviving machineries in the CPE-treated cells was notably protected against the oxidative insult | - |
dc.description.sponsorship | This work was supported by grants AGL2010-17579 and project CSD2007-00063 from Programa Consolider-Ingenio from the Spanish Ministry of Economy and Competitivity. | - |
dc.language.iso | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation.isversionof | Publisher's version | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Dietary polyphenols | - |
dc.subject | Cocoa flavanols | - |
dc.subject | Ins-1E cells | - |
dc.subject | Oxidative biomarkers | - |
dc.subject | Type 2 diabetes mellitus | - |
dc.subject | Antioxidant defences | - |
dc.title | Cocoa phenolic extract protects pancreatic beta cells against oxidative stress | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/nu5082955 | - |
dc.relation.publisherversion | https://doi.org/10.3390/nu5082955 | - |
dc.date.updated | 2013-12-02T13:07:49Z | - |
dc.description.version | Peer Reviewed | - |
dc.rights.license | http://creativecommons.org/licenses/by/3.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 23912326 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Cocoa_phenolics.pdf | 402,31 kB | Adobe PDF | Visualizar/Abrir |
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