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Título: | Comparative evolutionary and structural analyses of the TYRP1 gene reveal molecular mechanisms of biological functions in mammals |
Autor: | Ali, Hina; Mahmood, Mahreen; Adnan, Muhammad; Afzal, Gulnaz; Perween, Shazia; Waseem Akhtar, Rana; Jabeen, Raheela; Rasool Asif, Akhtar; Faryal, Sehrish; Rahman, Abdur; Muhammad, Sayyed Aun; Parveen, Gulnaz; Ahmed, Shakeel CSIC; Ali, Daoud; Almarzoug, Mohammed H.A. | Palabras clave: | Evolution Tyrosine Mammals Adaptive selection Phylogenetics |
Fecha de publicación: | 2023 | Editor: | Elsevier | Citación: | Journal of King Saud University - Science 35(6): 102772 (2023) | Resumen: | Molecular mechanisms underlying adaptation to the environments are still challenging in evolutionary biology. This study conducted a comparative analysis of tyrosine protein across different mammalian species to gain insight into the molecular mechanisms of adaptive evolution in response to oxidative stress. By examining tyrosine protein's structural and evolutionary patterns, the study identified specific amino acid residues that may have played a role in adaptive evolution in response to oxidative stress. We examined this protein's structural and evolutionary patterns and identified specific amino acid residues that may have played a role in adaptive evolution. Our results suggest that changes in the tyrosine protein may have contributed to the evolution of antioxidant defense mechanisms in mammals. We also reconstructed the evolutionary history of tyrosine protein in mammals and identified key events and lineages that may have contributed to the observed patterns of adaptation. These findings provide valuable insights into the molecular mechanisms that underlie adaptive evolution in response to environmental stressors and highlight the importance of the tyrosine protein in the evolution of antioxidant defense systems in mammals. The results suggest that changes in the tyrosine protein may have contributed to the evolution of antioxidant defense mechanisms in mammals. These findings provide a deeper understanding of the molecular mechanisms that underlie adaptive evolution in response to environmental stressors. | Versión del editor: | https://doi.org/10.1016/j.jksus.2023.102772 | URI: | http://hdl.handle.net/10261/341727 | DOI: | 10.1016/j.jksus.2023.102772 | ISSN: | 1018-3647 | Referencias: | Corrigendum to “Molecular evolution of the pathogen recognition peptidoglycan proteins regulates the immune response against infectious diseases in Drosophila melanogaster” [J. King Saud Univ.-Sci. 35(5) (2023) 102710] Journal of King Saud University - Science, Volume 35, Issue 7, October 2023, Pages 102854 Muhammad Ehsan Khalid, Afifa Zafar, Zubia Zafar, Hafiz Ishfaq Ahmad, Akhtar Rasool Asif, Muhammad Essa, Abdur Rahman, Sayyed Aun Muhammad, Maryam Raana, Fahad Saleem, Daoud Ali, Mohammed H.A. Almarzoug, Gokhlesh Kumar |
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