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Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships

AuthorsAlonso De Diego, Sergio A.; Muñoz, Pilar; González-Muñiz, Rosario CSIC ORCID; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa CSIC ORCID; García-López, M. Teresa CSIC
KeywordsGly-Pro-Glu (GPE)
Structure–activity relationships
Issue Date3-Mar-2005
CitationBioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)
AbstractA series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2005.03.015
Appears in Collections:(CENQUIOR) Artículos
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