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dc.contributor.authorAlonso De Diego, Sergio A.-
dc.contributor.authorMuñoz, Pilar-
dc.contributor.authorGonzález-Muñiz, Rosario-
dc.contributor.authorCenarruzabeitia, Edurne-
dc.contributor.authorFrechilla, Diana-
dc.contributor.authorRío, Joaquín del-
dc.contributor.authorJimeno, M. Luisa-
dc.contributor.authorGarcía-López, M. Teresa-
dc.date.accessioned2011-03-23T12:12:31Z-
dc.date.available2011-03-23T12:12:31Z-
dc.date.issued2005-03-03-
dc.identifier.citationBioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/33717-
dc.description.abstractA series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish Ministry of Education and Science (SAF2003-07207-C02). S.A.A.D.D. holds a predoctoral fellowship from this Ministry for Associated Units to CSIC.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectGly-Pro-Glu (GPE)es_ES
dc.subjectNeuroprotectiones_ES
dc.subjectStructure–activity relationshipses_ES
dc.titleAnalogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationshipses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/doi:10.1016/j.bmcl.2005.03.015-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bmcl.2005.03.015es_ES
dc.identifier.e-issn0960-894X-
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