2024-03-28T16:35:38Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/337172014-03-21T13:53:27Zcom_10261_100com_10261_5col_10261_353
00925njm 22002777a 4500
dc
Alonso De Diego, Sergio A.
author
Muñoz, Pilar
author
González-Muñiz, Rosario
author
Cenarruzabeitia, Edurne
author
Frechilla, Diana
author
Río, Joaquín del
author
Jimeno, M. Luisa
author
García-López, M. Teresa
author
2005-03-03
A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in the biological responses, while the preference for cis or trans rotamers around the Gly-Pro peptide bond is not important.
Bioorganic & Medicinal Chemistry Letters 15 : 2279–2283 (2005)
http://hdl.handle.net/10261/33717
10.1016/j.bmcl.2005.03.015
0960-894X
Gly-Pro-Glu (GPE)
Neuroprotection
Structure–activity relationships
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure–activity relationships