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dc.contributor.author | Santos-Lozano, J. M. | es_ES |
dc.contributor.author | Rada, Mirella | es_ES |
dc.contributor.author | Lapetra, José | es_ES |
dc.contributor.author | Guinda Garín, M. Ángeles | es_ES |
dc.contributor.author | Jiménez-Rodríguez, María C. | es_ES |
dc.contributor.author | Cayuela, José Antonio | es_ES |
dc.contributor.author | Ángel-Lugo, Antonio | es_ES |
dc.contributor.author | Vilches-Arenas, Ángel | es_ES |
dc.contributor.author | Gómez-Martín, Ana M. | es_ES |
dc.contributor.author | Ortega-Calvo, Manuel | es_ES |
dc.contributor.author | Castellano, José María | es_ES |
dc.date.accessioned | 2020-01-17T11:26:49Z | - |
dc.date.available | 2020-01-17T11:26:49Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | Diabetes, Obesity and Metabolism. A Journal of Pharmacology and Therapeutics 21 (11): 2526-2534 (2019) | es_ES |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | http://hdl.handle.net/10261/198205 | - |
dc.description | 26 Páginas.-- 3 Tablas.-- 2 Figuras | es_ES |
dc.description.abstract | Aim To assess whether the regular intake of an oleanolic acid (OA)‐enriched olive oil is effective in the prevention of diabetes. Methods In the PREDIABOLE study, prediabetic individuals (impaired fasting glucose and impaired glucose tolerance) of both sexes (176 patients, aged 30‐80 years) were randomized to receive 55 mL/day of OA‐enriched olive oil (equivalent dose 30 mg OA/day) [intervention group (IG)] or the same oil not enriched [control group (CG)]. The main outcome was the incidence of new‐onset type 2 diabetes in both groups. Results Forty‐eight new diabetes cases occurred, 31 in the CG and 17 in the IG. The multivariate‐adjusted hazard ratio was 0.45 (95% CI, 0.24‐0.83) for the IG compared with the CG. Intervention‐related adverse effects were not reported. Conclusions The intake of OA‐enriched olive oil reduces the risk of developing diabetes in prediabetic patients. The results of the PREDIABOLE study promote the use of OA in new functional foods and drugs for the prevention of diabetes in individuals at risk of developing it. | es_ES |
dc.description.sponsorship | The authors especially thank the ACESUR Group (Dos Hermanas, Seville, Spain), which donated all the commercial olive oil for the trial. This collaborator had no role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. The authors also express their gratitude to Dr. Alberto Gil‐Peralta, Neurology Service of the Virgen del Rocío University Hospital (Seville, Spain), for the critical reading of the manuscript and his helpful comments. CIBEROBN is an initiative of Instituto de Salud Carlos III (ISCIII), Madrid, Spain. The PREDIABOLE study was supported by the official funding agency for biomedical research of the Spanish Government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co‐funded by the European Regional Development Fund, including the following projects: PI10/00913 (led by J.M.S.‐L.) and PI10/01415 (led by J.A.C.). The study was also supported by a grant of Consejería de Salud de la Junta de Andalucía (PI‐0037/2008, led by J.M.S.‐L.). None of the funding sources took part in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | antidiabetic drug | es_ES |
dc.subject | Oleanolic acid | es_ES |
dc.subject | phase I‐II study | es_ES |
dc.subject | primary care | es_ES |
dc.subject | randomized trial | es_ES |
dc.subject | randomized trial type 2 diabetes | es_ES |
dc.title | Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1111/dom.13838 | es_ES |
dc.identifier.e-issn | 1463-1326 | - |
dc.embargo.terms | 2020-11-01 | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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PostP_2019_DOM_V21_P2526.pdf | Artículo principal | 514,14 kB | Adobe PDF | Visualizar/Abrir |
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