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http://hdl.handle.net/10261/190363
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Bermúdez-Oria, Alejandra | es_ES |
dc.contributor.author | Rodríguez-Gutiérrez, Guillermo | es_ES |
dc.contributor.author | Alaíz Barragán, Manuel | es_ES |
dc.contributor.author | Vioque, Javier | es_ES |
dc.contributor.author | Girón-Calle, Julio | es_ES |
dc.contributor.author | Fernández-Bolaños Guzmán, Juan | es_ES |
dc.date.accessioned | 2019-09-10T11:15:55Z | - |
dc.date.available | 2019-09-10T11:15:55Z | - |
dc.date.issued | 2019-07-15 | - |
dc.identifier.citation | Food and Function 10: 4844-4853 (2019) | es_ES |
dc.identifier.issn | 2042-6496 | - |
dc.identifier.uri | http://hdl.handle.net/10261/190363 | - |
dc.description | 30 Páginas.-- 5 Figuras.-- 2 Tablas | es_ES |
dc.description.abstract | Three olive modified pectin extracts have been produced by heat and acid treatment of the major by-product of olive oil production. Their effect on proliferation of the colon carcinoma Caco-2 and the leukemia monocytic THP-1 cell lines has been studied in order to determine possible anti-tumor properties. All extracts inhibited proliferation at some of the concentrations ranging from 1 to 10 mg ml−1. Interestingly none of the extracts inhibited the growth of confluent Caco-2 cells, showing the specificity of the antiproliferative effect for the transformed Caco-2 phenotype. All the extracts inhibited agglutination of red blood cells by galectin-3, a lectin involved in tumor growth, metastasis, and immune cell regulation that has been proposed as a mediator of the anti-tumor effects of modified pectins. In addition, activation of caspase-3 in THP-1 cells indicates that treatment with the pectin-rich extracts triggers apoptosis. These results point to a possible use as health-promoting food ingredients or supplements. | es_ES |
dc.description.sponsorship | This research was supported by the Spanish Ministry of Economy, Industry and Competitiveness and co-funded by a European Social Fund (ESF) (Ramon y Cajal Programme Grant 2012-10456; AGL2013-48291-R; and AGL2016-79088-R). A. Bermúdez-Oria received funding from the Spanish FPI program (MEIC) (BES-2014-068508). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48291-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79088-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.title | Pectin-rich extracts from olives inhibit proliferation of Caco-2 and THP-1 cells | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/C9FO00917E | es_ES |
dc.identifier.e-issn | 2042-650X | - |
dc.embargo.terms | 2020-07-15 | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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PostP_2019_FoodFunct_V10_P4844.pdf | Artículo principal | 761,53 kB | Adobe PDF | Visualizar/Abrir |
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