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Dietary fatty acids on aortic root calcification in mice with metabolic syndrome

AutorNaranjo, María C.; Bermúdez, Beatriz ; García, Indara; López, Sergio ; Abia, Rocío ; Muriana, Francisco J. G. ; Montserrat-de la Paz, Sergio
Fecha de publicación24-feb-2017
EditorRoyal Society of Chemistry (Great Britain)
CitaciónFood and Function
ResumenMetabolic syndrome (MetS) is associated with obesity, dyslipidemia, type 2 diabetes, and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on vascular calcification by the modulation of the RANKL/RANK/OPG system in the aortic roots of Lepob/obLDLR−/− mice. Animals fed with HFLCD-SFAs had increased weight and a greater atheroma plaque size, calcification, and RANKL/CATHK expression in the aortic root than mice on MUFA-enriched diets, with an increasing OPG expression in the aortic roots of the latter. Our study demonstrates that compared to dietary SFAs, MUFAs from olive oil protect against atherosclerosis by interfering with vascular calcification via the RANKL/RANK/OPG system in the setting of MetS. These findings open opportunities for developing novel nutritional strategies with olive oil as the most important dietary source of MUFAs (notably oleic acid) to prevent cardiovascular complications in MetS.
Descripción21 Páginas, 3 Figuras, 3 Tablas
Versión del editorhttp://dx.doi.org/10.1039/C7FO00143F
URIhttp://hdl.handle.net/10261/167255
ISSN2042-6496
E-ISSN2042-650X
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