English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/115755
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
 |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)

Dietary fatty acids and vitamin B3: an effective treatment strategy for the metabolic syndrome?

Autor Montserrat-de la Paz, Sergio ; López, Sergio ; Ortega, Almudena ; Varela, Lourdes; Abia, Rocío ; Muriana, Francisco J. G. ; Bermúdez, Beatriz
Palabras clave Omega-3 PUFAs
Dietary oleic acid
Cardiovascular diseases
Metabolic syndrome
Fecha de publicación 2014
Citación The Journal of Food & Nutritional Disorders 3: 6 (2014)
ResumenThe metabolic syndrome (MS) may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension. Recent evidences suggest that, primarily due to its high monounsaturated fatty acids (MUFAs) content, olive oil and omega-3 polyunsaturated fatty acids (PUFAs) could be useful as a dietary approach for MS management, with relevance in the postprandial state. Vitamin B3, as a major substrate for nicotinamide phosphoribosyltransferase (NAMPT), also constitutes a nutritional intervention strategy for the treatment of MS. NAMPT has been shown to exert activities of central importance to cellular energetics and innate immunity. Within the cell, NAMPT is the rate-limiting step in a salvage pathway of nicotinamide adenine dinucleotide (NAD+) biosynthesis. NAMPT has been shown to correlate with triglycerides in the fasting plasma, and a potential regulatory role for fatty acids on NAMPT expression has been proposed. Whether different dietary fatty acids, including olive oil as a source of MUFA, play a role in NAMPT excursions and in the NAMPT-dependent regulation of glucose and lipid metabolism and inflammation states remains to be solved. In general, the mechanisms that alter NAD+ metabolism probably include multiple processes, but the understandings of these mechanisms are currently very unclear and a considerable effort in this area is required before we know how changes in NAD+ metabolism influence physiology of glucose and lipid metabolism and how NAD+ metabolism might be manipulated for healing benefit by specific dietary fatty acids as a therapeutic treatment for MS.
URI http://hdl.handle.net/10261/115755
Identificadoresdoi: 10.4172/2324-9323.1000157
issn: 2324-9323
Aparece en las colecciones: (IG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Postprint_JFND_2014_6.pdf827,33 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.