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dc.contributor.authorMuthaiyan, A.-
dc.contributor.authorHernández-Hernández, Oswaldo-
dc.contributor.authorMoreno, F. Javier-
dc.contributor.authorSanz, M. Luz-
dc.contributor.authorRicke, S. C.-
dc.date.accessioned2014-08-28T09:47:15Z-
dc.date.available2014-08-28T09:47:15Z-
dc.date.issued2012-
dc.identifierdoi: 10.1021/jf301392y-
dc.identifierissn: 0021-8561-
dc.identifiere-issn: 1520-5118-
dc.identifier.citationJournal of Agricultural and Food Chemistry 60(27): 6839-6845 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/101337-
dc.description.abstractIn this study bioactive caseinomacropeptide was conjugated with prebiotic galactooligosaccharides (hCMP:GOS) by Maillard reaction to synthesize value added prebiotic compounds to Lactobacillus strains. Growth study showed the ability of hCMP:GOS to serve as a sole carbon source for Lactobacillus strains. A significant amount of acetate and lactate was detected in cell free culture supernatant by HPLC. It demonstrated the ability of Lactobacillus strains to ferment the hCMP:GOS as a carbon source. In addition, hCMP:GOS grown Lactobacillus cells exhibited enhanced bile tolerance and retained 90% viability. Overall results of this study indicate that the hCMP conjugated GOS can be potential multipurpose prebiotic substrates to enhance the growth and bile tolerance in Lactobacillus strains and serve as a fermentable substrate to produce beneficial metabolites in the host. © 2012 American Chemical Society.-
dc.description.sponsorshipWe gratefully acknowledge financial support from Junta de Castilla-La Mancha and European regional development fund (ERDF) (POII10-0178-4685), from Comunidad Autónoma de Madrid (ALIBIRD S2009/AGR-1469), and from Ministerio de Ciencia e Innovación (AGL2011-27884). S.C.R. received support from a USDA Food Safety Consortium and a USDA-NIFSI (2008-51110-04339) grant. O.H.-H. thanks the CSIC for a JAE-PreDoc PhD grant.-
dc.publisherAmerican Chemical Society-
dc.relationS2009/AGR-1469/ALIBIRD-
dc.rightsclosedAccess-
dc.subjectProbiotic-
dc.subjectLactobacillus-
dc.subjectGalactooligosaccharides-
dc.subjectPrebiotic-
dc.titleHydrolyzed caseinomacropeptide conjugated galactooligosaccharides support the growth and enhance the bile tolerance in lactobacillus strains-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1021/jf301392y-
dc.date.updated2014-08-28T09:47:15Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderJunta de Comunidades de Castilla-La Mancha-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderDepartment of Agriculture (US)-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000199es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011698es_ES
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