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http://hdl.handle.net/10261/93188
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martín, M. Ángeles | - |
dc.contributor.author | Fernández-Millán, Elisa | - |
dc.contributor.author | Ramos, Sonia | - |
dc.contributor.author | Bravo, Laura | - |
dc.contributor.author | Goya, Luis | - |
dc.date.accessioned | 2014-03-07T07:26:10Z | - |
dc.date.available | 2014-03-07T07:26:10Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Molecular Nutrition and Food Research 58(3): 447–456 (2014) | es_ES |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/10261/93188 | - |
dc.description.abstract | [Scope] Diabetes mellitus is associated with reductions in glutathione, supporting the critical role of oxidative stress in its pathogenesis. Antioxidant food components such as flavonoids have a protective role against oxidative stress-induced degenerative and age-related diseases. Flavonoids such as epicatechin (EC) constitute an important part of the human diet; they can be found in green tea, grapes, and cocoa and possess multiple biological activities. This study investigates the chemo-protective effect of EC against oxidative stress induced by tert-butylhydroperoxide (t-BOOH) on Ins-1E pancreatic beta cells. | es_ES |
dc.description.abstract | [Methods and Results] Cell viability, oxidative status, phosphorylated Jun kinase (p-JNK) expression, and insulin secretion were evaluated. Ins-1E cells treatment with 5-20 μM EC for 20 h evoked no cell damage and enhanced antioxidant enzymes and insulin secretion. Addition of 50 μM t-BOOH for 2 h induced reactive oxygen species, p-JNK, and carbonyl groups and decreased GSH and insulin secretion. Pretreatment of cells with EC prevented the t-BOOH-induced reactive oxygen species, carbonyl groups, p-JNK expression and cell death, and recovered insulin secretion. | es_ES |
dc.description.abstract | [Conclusion] Ins-1E cells treated with EC showed a remarkable recovery of cell viability and insulin secretion damaged by t-BOOH, indicating that integrity of secreting and surviving machineries in the EC-treated cells was notably protected against the oxidative insult. | es_ES |
dc.description.sponsorship | This work was supported by grants AGL2010–17579 and project CSD2007–00063 from Programa Consolider-Ingenio from the Spanish Ministry of Economy and Competitivity. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH | es_ES |
dc.relation.isversionof | Preprint | - |
dc.rights | openAccess | es_ES |
dc.subject | Antioxidant defences | es_ES |
dc.subject | Cocoa flavanols | es_ES |
dc.subject | Dietary polyphenols | es_ES |
dc.subject | Oxidative biomarkers | es_ES |
dc.subject | Type 2 diabetes mellitus | es_ES |
dc.title | Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/mnfr.201300291 | - |
dc.relation.publisherversion | https://doi.org/10.1002/mnfr.201300291 | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 24115486 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Cocoa_flavonoid_epicatechin_protects.pdf | 413,54 kB | Adobe PDF | Visualizar/Abrir |
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