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Título: | Smallest Peptoids with Antiproliferative Activity on Human Neoplastic Cells |
Autor: | Mas Moruno, Carlos; Cruz, Luis J.; Mora, Puig; Francesch, Andrés; Messeguer Peypoch, Ángel CSIC ORCID; Pérez-Payá, Enrique CSIC; Albericio, Fernando CSIC ORCID | Palabras clave: | Peptoids Antiproliferative activity Solid phase synthesis Diketopiperazines |
Fecha de publicación: | 4-abr-2007 | Editor: | American Chemical Society | Citación: | Journal Medicinal Chemistry Research; vol 50, 2443-2449 | Resumen: | Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis. | Descripción: | 7 paginas; 5 tablas; 2 esquemas. | Versión del editor: | http://dx.doi.org/10.1021/jm061166z | URI: | http://hdl.handle.net/10261/9250 | DOI: | 10.1021/jm061166z | ISSN: | 1554-8120 |
Aparece en las colecciones: | (IQAC) Artículos (IBV) Artículos |
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