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http://hdl.handle.net/10261/5779
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fernández, Matilde | - |
dc.contributor.author | Martínez-Bueno, M. | - |
dc.contributor.author | Martín, M. Cruz | - |
dc.contributor.author | Valdivia, E. | - |
dc.contributor.author | Maqueda, M. | - |
dc.date.accessioned | 2008-07-11T11:47:46Z | - |
dc.date.available | 2008-07-11T11:47:46Z | - |
dc.date.issued | 2007-05 | - |
dc.identifier.citation | Journal of Applied Microbiology 102(5): 1350-1361 (2007) | en_US |
dc.identifier.issn | 1364-5072 | - |
dc.identifier.uri | http://hdl.handle.net/10261/5779 | - |
dc.description.abstract | [Aims] Enterococcus faecalis produces a cationic and circular enterocin, AS-48, of 7149 Da, the genetic determinants of which are located within the pMB2 plasmid. We have compared enterocin AS-48 production by different enterococci species with that of other `safe' lactic acid bacteris (LAB) (GRAS status) and looked into the subsequent application of this enterocin in food production. | en_US |
dc.description.abstract | [Methods and Results] In an effort to exploit this system for the heterologous expression of enterocin AS-48, a number of vectors containing the as-48 cluster were constructed and used to transform several LAB strains (genera Enterococcus, Lactococcus and Lactobacillus). | en_US |
dc.description.abstract | [Conclusion] Heterologous production of enterocin AS-48 failed when bacteria other than those belonging to the genus Enterococcus were used as hosts, although expression of a partial level of resistance against AS-48 were always detected, ruling out the possibility of a lack of recognition of the enterococcal promoters. | en_US |
dc.description.abstract | [Significance and Impact of the Study] Our results reveal the special capacity of species from the genus Enterococcus to produce AS-48, an enterocin that requires a post-transcriptional modification to generate a circular peptide with a wide range of inhibitory activity against pathogenic and spoilage bacteria. Preliminary experiments in foodstuffs using nonvirulent enterococci with interesting functional properties reveal the possibility of a biotechnological application of these transformants. | en_US |
dc.description.sponsorship | This study was supported by the Spanish Dirección General de Investigación Científica y Técnica (Project BIO98-0908-CO2-01) and Grupo de Investigación de la Junta de Andalucía (CIV 016). M. Fernández received a fellowship from the Spanish Ministry of Education, Culture and Sports. | en_US |
dc.format.extent | 22195 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Blackwell Publishing | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Bacteriocin | en_US |
dc.subject | Circular Antimicrobial Peptide | en_US |
dc.subject | Enterococcus | en_US |
dc.subject | Lactobacillus | en_US |
dc.subject | Lactococcus | en_US |
dc.title | Heterologous expression of enterocin AS-48 in several strains of lactic acid bacteria | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1111/j.1365-2672.2006.03194.x | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1365-2672.2006.03194.x | - |
dc.contributor.funder | Dirección General de Investigación Científica y Técnica, DGICT (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100008737 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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