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Título: | Fighting pathogenic yeasts with plant defensins and anti-fungal proteins from fungi |
Autor: | Manzanares, Paloma CSIC ORCID; Giner-Llorca, Moisés; Marcos López, José Francisco CSIC ORCID ; Garrigues, Sandra CSIC ORCID | Palabras clave: | Anti-fungal proteins (AFPs) Anti-yeast potency Biotechnological production Mode of action Plant defensins |
Tesauro UNESCO: | Biotechnology | Tesauro AGROVOC: | antifungal properties proteins |
Fecha de publicación: | 27-mar-2024 | Editor: | Springer Nature | Citación: | Applied Microbiology and Biotechnology 108(1): 277 (2024) | Resumen: | Fungal infections represent a significant health risk worldwide. Opportunistic infections caused by yeasts, particularly by Candida spp. and their virulent emerging isolates, have become a major threat to humans, with an increase in fatal cases of infections attributed to the lack of effective anti-yeast therapies and the emergence of fungal resistance to the currently applied drugs. In this regard, the need for novel anti-fungal agents with modes of action different from those currently available is undeniable. Anti-microbial peptides (AMPs) are promising candidates for the development of novel anti-fungal biomolecules to be applied in clinic. A class of AMPs that is of particular interest is the small cysteine-rich proteins (CRPs). Among CRPs, plant defensins and anti-fungal proteins (AFPs) of fungal origin constitute two of the largest and most promising groups of CRPs showing anti-fungal properties, including activity against multi-resistant pathogenic yeasts. In this review, we update and compare the sequence, structure, and properties of plant defensins and AFPs with anti-yeast activity, along with their in vitro and in vivo potency. We focus on the current knowledge about their mechanism of action that may lead the way to new anti-fungals, as well as on the developments for their effective biotechnological production. KEY POINTS: • Plant defensins and fungal AFPs are alternative anti-yeast agents • Their multi-faceted mode of action makes occurrence of resistance rather improbable • Safe and cost-effective biofactories remain crucial for clinical application. | Versión del editor: | https://doi.org/10.1007/s00253-024-13118-1 | URI: | http://hdl.handle.net/10261/353503 | DOI: | 10.1007/s00253-024-13118-1 | ISSN: | 1432-0614 | E-ISSN: | 0175-7598 |
Aparece en las colecciones: | (IATA) Artículos |
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AMB2024-Manzanares.pdf | Artículo principal | 2,56 MB | Adobe PDF | Visualizar/Abrir |
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