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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Manzanares, Paloma | es_ES |
dc.contributor.author | Giner-Llorca, Moisés | es_ES |
dc.contributor.author | Marcos López, José Francisco | es_ES |
dc.contributor.author | Garrigues, Sandra | es_ES |
dc.date.accessioned | 2024-04-11T07:52:45Z | - |
dc.date.available | 2024-04-11T07:52:45Z | - |
dc.date.issued | 2024-03-27 | - |
dc.identifier.citation | Applied Microbiology and Biotechnology 108(1): 277 (2024) | es_ES |
dc.identifier.issn | 1432-0614 | - |
dc.identifier.other | CEX2021-001189-S | - |
dc.identifier.uri | http://hdl.handle.net/10261/353503 | - |
dc.description.abstract | Fungal infections represent a significant health risk worldwide. Opportunistic infections caused by yeasts, particularly by Candida spp. and their virulent emerging isolates, have become a major threat to humans, with an increase in fatal cases of infections attributed to the lack of effective anti-yeast therapies and the emergence of fungal resistance to the currently applied drugs. In this regard, the need for novel anti-fungal agents with modes of action different from those currently available is undeniable. Anti-microbial peptides (AMPs) are promising candidates for the development of novel anti-fungal biomolecules to be applied in clinic. A class of AMPs that is of particular interest is the small cysteine-rich proteins (CRPs). Among CRPs, plant defensins and anti-fungal proteins (AFPs) of fungal origin constitute two of the largest and most promising groups of CRPs showing anti-fungal properties, including activity against multi-resistant pathogenic yeasts. In this review, we update and compare the sequence, structure, and properties of plant defensins and AFPs with anti-yeast activity, along with their in vitro and in vivo potency. We focus on the current knowledge about their mechanism of action that may lead the way to new anti-fungals, as well as on the developments for their effective biotechnological production. KEY POINTS: • Plant defensins and fungal AFPs are alternative anti-yeast agents • Their multi-faceted mode of action makes occurrence of resistance rather improbable • Safe and cost-effective biofactories remain crucial for clinical application. | es_ES |
dc.description.sponsorship | Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by grant PID2021-125858OB-100 and the Severo Ochoa Excellence Program CEX2021-001189-S funded by MCIN/AEI/ https://doi.org/10.13039/501100011033 and by “ERDF: A way of making Europe.” This study forms part of the AGROALNEXT program and was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) and by Generalitat Valenciana. S. G. holds a Juan de la Cierva Incorporación grant (IJC2020-042749-I) funded by MCIN/AEI/ https://doi.org/10.13039/501100011033, “ERDF: A way of making Europe” and ‘NextGenerationEU/PRTR.’ M. G. L. was a recipient of a predoctoral grant FPU19/02066 funded by MCIN/AEI/ https://doi.org/10.13039/501100011033 and by “ESF: Investing in your future.” | es_ES |
dc.description.sponsorship | With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX 2021-001189-S) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX 2021-001189-S | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125858OB-I00/ES/HACIA LA APLICACION DE LAS PROTEINAS ANTIFUNGICAS DE HONGOS (AFPS): DESCIFRANDO SU ACCION ANTIFUNGICA Y PAPEL BIOLOGICO MEDIANTE EDICION GENETICA Y BIOLOGIA SINTETICA/ | es_ES |
dc.relation.ispartof | Applied microbiology and biotechnology | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Anti-fungal proteins (AFPs) | es_ES |
dc.subject | Anti-yeast potency | es_ES |
dc.subject | Biotechnological production | es_ES |
dc.subject | Mode of action | es_ES |
dc.subject | Plant defensins | es_ES |
dc.title | Fighting pathogenic yeasts with plant defensins and anti-fungal proteins from fungi | es_ES |
dc.type | artículo de revisión | es_ES |
dc.identifier.doi | 10.1007/s00253-024-13118-1 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1007/s00253-024-13118-1 | es_ES |
dc.identifier.e-issn | 0175-7598 | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.contributor.orcid | 0000-0001-5036-9787 | es_ES |
dc.contributor.orcid | #NODATA# | es_ES |
dc.contributor.orcid | #NODATA# | es_ES |
dc.contributor.orcid | #NODATA# | es_ES |
dc.identifier.pmid | 38536496 | - |
dc.identifier.scopus | 2-s2.0-85189258592 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85189258592 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_dcae04bc | es_ES |
dc.subject.sdg | Ensure healthy lives and promote well-being for all at all ages | es_ES |
dc.subject.agrovoc | antifungal properties | es_ES |
dc.subject.agrovoc | proteins | es_ES |
dc.subject.unesco | Biotechnology | es_ES |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo de revisión | - |
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AMB2024-Manzanares.pdf | Artículo principal | 2,56 MB | Adobe PDF | Visualizar/Abrir |
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