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http://hdl.handle.net/10261/285057
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Villalva, Marisol | es_ES |
dc.contributor.author | Silván, José Manuel | es_ES |
dc.contributor.author | Alarcón, Teresa | es_ES |
dc.contributor.author | Villanueva-Bermejo, David | es_ES |
dc.contributor.author | Jaime, Laura | es_ES |
dc.contributor.author | Santoyo, Susana | es_ES |
dc.contributor.author | Martínez-Rodríguez, Adolfo J. | es_ES |
dc.date.accessioned | 2022-12-16T11:58:18Z | - |
dc.date.available | 2022-12-16T11:58:18Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Antioxidants 11(10): 1849 (2022) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/285057 | - |
dc.description | This article belongs to the Special Issue Advances in the Astonishing World of Phytochemicals: State-of-the-Art for Antioxidants. | es_ES |
dc.description.abstract | The main objective of this work is to evaluate the potential utility of an Achillea millefolium extract (yarrow extract, YE) in the control of H. pylori infection. The supercritical anti-solvent fractionation (SAF) process of YE allowed the obtaining of two different fractions: yarrow’s precipitated fraction (YPF), enriched in most polar phenolic compounds (luteolin-7-O-glucoside, luteolin, and 3,5-dicaffeoylquinic acid), and yarrow’s separator fraction (YSF), enriched in monoterpenes and sesquiterpenes, mainly containing camphor, artemisia ketone, and borneol. YE was effective in reducing reactive oxygen species (ROS) production in human gastric AGS cells by 16% to 29%, depending on the H. pylori strain. YPF had the highest inhibitory activity (38–40%) for ROS production. YE modulated the inflammatory response in AGS gastric cells, decreasing IL-8 production by 53% to 64%. This IL-8 inhibition also showed a strain-dependent character. YPF and YSF exhibited similar behavior, reducing IL-8 production, suggesting that both phenolic compounds and essential oils could contribute to IL-8 inhibition. YSF showed the highest antibacterial activity against H. pylori (6.3–7.1 log CFU reduction, depending on the strain) and lower MIC (0.08 mg/mL). Results obtained have shown that YE and SAF fractions (YPF and YSF) were effective as antioxidant, anti-inflammatory, and antibacterial agents regardless of the H. pylori strain characteristics. | es_ES |
dc.description.sponsorship | This research was funded by Projects AGL2017-89566-R (HELIFOOD) (MCIN/AEI/10.13039/501100011033/ (Spanish Ministry of Science and Innovation) and Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa”) and ALIBIRD-CM2020 P2018/BAA-4343 (Comunidad de Madrid, Spain). | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89566-R/ES/REVALORIZACION DE SUBPRODUCTOS DE LA INDUSTRIA ALIMENTARIA COMO FUENTE DE COMPUESTOS BIOACTIVOS UTILES PARA LA MITIGACION DE LA INFECCION HUMANA POR HELICOBACTER PYLORI/ | es_ES |
dc.relation | P2018/BAA-4343/ALIBIRD-CM2020 | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/antiox11101849 | - |
dc.rights | openAccess | es_ES |
dc.subject | Achillea millefolium | es_ES |
dc.subject | Antibacterial activity | es_ES |
dc.subject | Yarrow extract | es_ES |
dc.subject | Antioxidant activity | es_ES |
dc.subject | H. pylori | es_ES |
dc.subject | Anti-inflammatory activity | es_ES |
dc.subject | Supercritical anti-solvent fractionation | es_ES |
dc.title | Antioxidant, anti-Inflammatory, and antibacterial properties of an Achillea millefolium L. extract and its fractions obtained by supercritical anti-solvent fractionation against Helicobacter pylori | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3390/antiox11101849 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/antiox11101849 | es_ES |
dc.identifier.e-issn | 2076-3921 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 36290572 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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