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Título: | Storage proteins are driving pediatric hazelnut allergy in a lipid transfer protein-rich area |
Autor: | Valbuena, Teresa; Reche, Marta; Marco, Guadalupe; Toboso, Inmaculada; Ringauf, Anna; Thuissard-Vasallo, Israel J.; Lozano-Ojalvo, Daniel CSIC ORCID; Martínez-Blanco, Mónica CSIC ORCID; Molina, Elena CSIC ORCID | Palabras clave: | Hazelnut allergy Severity Component-resolved diagnosis Food challenge Skin-prick test Specific IgE |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Foods 10(10): 2463 (2021) | Resumen: | Oral food challenge (OFC) remains the gold standard for the diagnosis of food allergies. However, this test is not without risks, given that severe allergic reactions can be triggered while it is conducted. The purpose of this study is to identify potential demographic variables, clinical characteristics of the patients and biomarkers that may be associated with severe reactions during the hazelnut oral challenge test. The sample included 22 children allergic to hazelnut who underwent a tree nut skin prick test (SPT), specific IgE (sIgE) to hazelnut, component-resolved diagnosis (CRD) with different hazelnut allergens (Cor a 1, Cor a 8, Cor a 9, Cor a 11, Cor a 14), and a single-blind placebo-controlled challenge with hazelnut. A statistically significant relationship was found between the severity of the reaction and the highest values of sIgE to hazelnut, Cor a 11 and Cor a 14, cumulative symptom-triggering dose and sunflower seed sensitization. The use of the CRD is a useful tool to identify patients at higher risk of developing a severe reaction. In this pediatric population sample from Spain, storage proteins were confirmed to be most involved in hazelnut allergy and the development of severe reactions. | Descripción: | This article belongs to the Special Issue Molecular Approaches to Food Allergy Diagnosis, Treatment and Identification of Allergens. | Versión del editor: | https://doi.org/10.3390/foods10102463 | URI: | http://hdl.handle.net/10261/263433 | DOI: | 10.3390/foods10102463 | E-ISSN: | 2304-8158 |
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