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Título: | Structure of i-Motif/Duplex Junctions at Neutral pH |
Autor: | Serrano-Chacón, Israel CSIC ORCID; Mir, Bartomeu CSIC ORCID; Escaja, Núria; González, Carlos CSIC | Fecha de publicación: | 9-ago-2021 | Editor: | American Chemical Society | Citación: | Journal of the American Chemical Society 143: 12919-12923 (2021) | Resumen: | We report here the three-dimensional structure of an i-motif/duplex junction, determined by NMR methods at neutral pH. By including a minor groove tetrad at one side of the C:C+ stack of a monomeric i-motif, and a stem/loop hairpin at the other side, we have designed stable DNA constructs in which i-DNA and B-DNA regions coexist in a wide range of experimental conditions. This study demonstrates that i- and B-DNA are structurally compatible, giving rise to a distinctive fold with peculiar groove shapes. The effect of different residues at the i-motif/duplex interface has been explored. We also show that these constructs can be adapted to sequences of biological relevance, like that found in the promoter region of the KRAS oncogene. | Descripción: | 5 pags., 4 figs. | Versión del editor: | http://dx.doi.org/10.1021/jacs.1c04679 | URI: | http://hdl.handle.net/10261/254158 | DOI: | 10.1021/jacs.1c04679 | Identificadores: | doi: 10.1021/jacs.1c04679 issn: 1520-5126 |
Aparece en las colecciones: | (IQF) Artículos |
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SeranoChacónI.pdf | 2,01 MB | Adobe PDF | Visualizar/Abrir | |
ELECTRONIC SUPPORTING INFORMATION.pdf | 25,25 MB | Adobe PDF | Visualizar/Abrir |
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