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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Serrano-Chacón, Israel | - |
dc.contributor.author | Mir, Bartomeu | - |
dc.contributor.author | Escaja, Núria | - |
dc.contributor.author | González, Carlos | - |
dc.date.accessioned | 2021-11-10T13:30:11Z | - |
dc.date.available | 2021-11-10T13:30:11Z | - |
dc.date.issued | 2021-08-09 | - |
dc.identifier | doi: 10.1021/jacs.1c04679 | - |
dc.identifier | issn: 1520-5126 | - |
dc.identifier.citation | Journal of the American Chemical Society 143: 12919-12923 (2021) | - |
dc.identifier.uri | http://hdl.handle.net/10261/254158 | - |
dc.description | 5 pags., 4 figs. | - |
dc.description.abstract | We report here the three-dimensional structure of an i-motif/duplex junction, determined by NMR methods at neutral pH. By including a minor groove tetrad at one side of the C:C+ stack of a monomeric i-motif, and a stem/loop hairpin at the other side, we have designed stable DNA constructs in which i-DNA and B-DNA regions coexist in a wide range of experimental conditions. This study demonstrates that i- and B-DNA are structurally compatible, giving rise to a distinctive fold with peculiar groove shapes. The effect of different residues at the i-motif/duplex interface has been explored. We also show that these constructs can be adapted to sequences of biological relevance, like that found in the promoter region of the KRAS oncogene. | - |
dc.description.sponsorship | This investigation was supported by research grants from the Spanish “Ministerio de Ciencia e Innovacioń ” (BFU2017- 89707-P, PID2020-116620GB-I00). | - |
dc.language | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-89707-P | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116620GB-I00 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Structure of i-Motif/Duplex Junctions at Neutral pH | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/jacs.1c04679 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jacs.1c04679 | - |
dc.date.updated | 2021-11-10T13:30:11Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (IQF) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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SeranoChacónI.pdf | 2,01 MB | Adobe PDF | Visualizar/Abrir | |
ELECTRONIC SUPPORTING INFORMATION.pdf | 25,25 MB | Adobe PDF | Visualizar/Abrir |
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