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dc.contributor.author | Wang, Julie Tzu-Wen | es_ES |
dc.contributor.author | Klippstein, Rebecca | es_ES |
dc.contributor.author | Martincic, Markus | es_ES |
dc.contributor.author | Pach, Elzbieta | es_ES |
dc.contributor.author | Feldman, Robert | es_ES |
dc.contributor.author | Šefl, Martin | es_ES |
dc.contributor.author | Michel, Yves | es_ES |
dc.contributor.author | Asker, Daniel | es_ES |
dc.contributor.author | Sosabowski, Jane K. | es_ES |
dc.contributor.author | Kalbáč, Martin | es_ES |
dc.contributor.author | Ros, Tatiana Da | es_ES |
dc.contributor.author | Ménard-Moyon, Cécilia | es_ES |
dc.contributor.author | Bianco, Alberto | es_ES |
dc.contributor.author | Kyriakou, Ioanna | es_ES |
dc.contributor.author | Emfietzoglou, Dimitris | es_ES |
dc.contributor.author | Saccavini, Jean-Claude | es_ES |
dc.contributor.author | Ballesteros, Belén | es_ES |
dc.contributor.author | Al-Jamal, Khuloud T. | es_ES |
dc.contributor.author | Tobias, Gerard | es_ES |
dc.date.accessioned | 2021-03-10T11:17:39Z | - |
dc.date.available | 2021-03-10T11:17:39Z | - |
dc.date.issued | 2020-01-28 | - |
dc.identifier.citation | ACS Nano 14(1): 129-141 (2020) | es_ES |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/10261/233878 | - |
dc.description.abstract | Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nanotubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing “cold” isotopically enriched samarium (152Sm), which can then be activated on demand to their “hot” radioactive form (153Sm) by neutron irradiation. The use of “cold” isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the “hot” nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy. | es_ES |
dc.description.sponsorship | This work received funding from the European Union’s Seventh Framework Programme (FP7-ITN Marie-Curie Actions, RADDEL, 290023). K.T.A.-J. acknowledges funding from Worldwide Cancer Research (12-1054), M.K. from MEYS (LTC18039), and G.T. from Agaur (2017 SGR 581). ICMAB and ICN2 acknowledge financial support from the Spanish Ministry of Economy and Competitiveness, through the “Severo Ochoa” Programme for Centres of Excellence in R&D (SEV-2015-0496 and SEV-2017-0706). This work was partly supported by the Centre National de la Recherche Scientifique (CNRS), by the Agence Nationale de la Recherche (ANR) through the LabEx project Chemistry of Complex Systems (ANR-10-LABX-0026_CSC), and by the International Center for Frontier Research in Chemistry (icFRC). We acknowledge support by MEYS CR and EU -ESIF in the frame of Operational Programme Research Development and Education - project Pro-NanoEnviCz (Project No. CZ.02.1.01/0.0/0.0/16_013/0001821). We thank Thomas Swan Co. Ltd. for supplying CNT Elicarb samples. We are grateful to S. Sandoval (ICMAB) and C. Ramos (IQS-ICMAB) for assessing the length and diameter distribution of CNTs. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/290023 | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MINECO/ICTI2013-2016/SEV-2015-0496 | es_ES |
dc.relation | SEV-2017-0706 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Cancer therapy | es_ES |
dc.subject | Nuclear imaging | es_ES |
dc.subject | Nanoencapsulation | es_ES |
dc.subject | Filled carbon nanotubes | es_ES |
dc.subject | Radiooncology | es_ES |
dc.subject | Nanooncology | es_ES |
dc.title | Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/acsnano.9b04898 | es_ES |
dc.embargo.terms | 2021-01-28 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Worldwide Cancer Research | es_ES |
dc.contributor.funder | Ministry of Education, Youth and Sports (Czech Republic) | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Centre National de la Recherche Scientifique (France) | es_ES |
dc.contributor.funder | Agence Nationale de la Recherche (France) | es_ES |
dc.contributor.funder | Centre International de Recherche aux Frontières de la Chimie (France) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001665 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004794 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007287 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100009120 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Wang_ACSNano_2020-postprint.docx | Artículo principal | 16,05 MB | Microsoft Word XML | Visualizar/Abrir |
Wang_ACSNano_2020_suppl_postprint.pdf | información complementaria | 5,69 MB | Adobe PDF | Visualizar/Abrir |
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