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Título: | Methicillin-resistant staphylococcus aureus in hospitals: Latest trends and treatments based on bacteriophages |
Autor: | Álvarez, Andrea; Fernández Llamas, Lucía CSIC ORCID; Gutiérrez, Diana CSIC ORCID; Iglesias, Beatriz; Rodríguez González, Ana CSIC ORCID; García Suárez, María Pilar CSIC ORCID | Palabras clave: | Staphylococcus aureus HA-MRSA CA-MRSA LA-MRSA Antibiotic resistance Soft-tissue infections Osteomyelitis Endocarditis Phage therapy Endolysins Bacteriophage therapy Bacteriophages Endolysin |
Fecha de publicación: | 22-nov-2019 | Editor: | American Society for Microbiology | Citación: | Journal of Clinical Microbiology 57: e01006-19 (2019) | Resumen: | Even though antibiotic resistance in bacteria is a natural phenomenon, the alarming increase in pathogenic bacteria refractory to a wide range of antimicrobials is attracting attention worldwide. Indeed, the World Health Organization (WHO) has recently published a list of priority pathogens for which new antimicrobial alternatives are urgently needed. Among these pathogens, methicillin-resistant Staphylococcus aureus (MRSA) strains are perhaps the best known by the general public. In addition to its potential to acquire antibiotic resistance, S. aureus can produce a large number of virulence factors, such as hemolysins, enterotoxins, and proteases, and exhibits the ability to form biofilms as well as to evolve into different clones that can spread and colonize new environments. This review provides a brief overview of the latest options in antibacterial therapies, mainly focusing on phage therapy. In this regard, the current stage of research about antimicrobial compounds based on bacteriophages and endolysins against MRSA infections is shown and discussed. | Versión del editor: | https://doi.org/10.1128/JCM.01006-19 | URI: | http://hdl.handle.net/10261/232113 | DOI: | 10.1128/JCM.01006-19 | ISSN: | 0095-1137 | E-ISSN: | 1098-660X |
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