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Título: | Probiotic yogurt for the prevention of antibiotic-associated diarrhea in adults. A randomized double-blind placebo-controlled trial |
Autor: | Velasco, María; Requena, Teresa CSIC ORCID ; Delgado-Iribarren, Alberto; Peláez, Carmen CSIC ORCID ; Guijarro, Carlos | Fecha de publicación: | 2019 | Editor: | Lippincott Williams & Wilkins | Citación: | Journal of Clinical Gastroenterology 53(10): 717-723 (2019) | Resumen: | [Goal]: To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients. [Background]: Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitalized adult population remains unclear. [Study]: A randomized, double-blind, placebo-controlled clinical trial was conducted in hospitalized patients who started antibiotic treatment. Patients were randomized (2:2:1) to receive a daily amount of 200 mL of placebo-yogurt (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus), 200 mL of probiotic yogurt (previous plus Lactobacillus acidophilus La-5, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus casei subsp. casei Lc-01 or no yogurt (unblinded control) within 48 hours of beginning the antibiotic therapy and up to 5 days after stopping the antibiotic. Patients were followed up with for 1 month to determine occurrence of diarrhea. [Results]: We included 314 patients, mean age 76 years. The rate of diarrhea was 23.0% in the probiotic group versus 17.6% in the placebo group, absolute risk reduction −5.35% (95% confidence interval, −15.4% to 4.7%; P=0.30). Rate of diarrhea was similar in the unblinded external control and in the blinded study groups combined (20.9% vs. 20.2% respectively; P=0.91). There was no difference in the duration of diarrhea, maximum number of bowel movements or prolonged admission because of diarrhea among the groups. All-cause mortality did not differ between groups. [Conclusions]: The combined probiotic strains LA-5, BB-12, and LC-01 do not have an effect in the prevention of AAD in hospitalized patients. |
Versión del editor: | https://doi.org/10.1097/MCG.0000000000001131 | URI: | http://hdl.handle.net/10261/204978 | DOI: | 10.1097/MCG.0000000000001131 | ISSN: | 0192-0790 | E-ISSN: | 1539-2031 |
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