Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/204106
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Antiparasitic Activity of Diterpenoids Against Trypanosoma cruzi |
Autor: | Alegre-Gómez, Sergio CSIC; Sainz, Paula; Simões, M..Fátima; Rijo, Patrícia; Moiteiro, Cristina; González-Coloma, Azucena CSIC ORCID; Martínez-Díaz, Rafael A. | Palabras clave: | Antitrypanosomal activity | Fecha de publicación: | 6-sep-2016 | Citación: | Planta Medica - Natural Products and Medicinal Plant Research | Resumen: | Twenty-seven diterpenes, including abietanes, labdanes, abeoabietanes, halimanes, and pimaranes, have been evaluated against epimastigote and intracellular amastigote forms of Trypanosoma cruzi and also against LC5 and NCTC cell lines. Royleanones (3, 4, and 5) and a further abietane (12), obtained by purification of Plectranthus spp. extracts, were the most active compounds on epimastigotes, showing IC50 values similar (1.73 µg/mL, 12) or even lower (0.39, 0.99, and 1.20 µg/mL, 3, 4, and 5 respectively) than the positive control nifurtimox (2.3 µg/mL). On intracellular amastigotes, abietanes 3, 4, and 5 showed a significant activity with IC50 values of 0.83, < 0.31, and 0.62 µg/mL, respectively, but were less potent than the positive control nifurtimox (IC50 < 0.16 µg/mL). Compounds 3, 4, and 5 were not cytotoxic to LC5 and NCTC 929 cells at 1 µg/mL. | URI: | http://hdl.handle.net/10261/204106 | DOI: | 10.1055/s-0042-115646 |
Aparece en las colecciones: | (ICA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Manuscript revised 30-05-2016.doc | Artículo | 1,01 MB | Microsoft Word | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
15
checked on 25-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 26-feb-2024
Page view(s)
190
checked on 28-abr-2024
Download(s)
122
checked on 28-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.