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dc.contributor.authorCilla, Antonioes_ES
dc.contributor.authorRodrigo, María Jesúses_ES
dc.contributor.authorZacarías, Lorenzoes_ES
dc.contributor.authorAncos, Begoña dees_ES
dc.contributor.authorSánchez-Moreno, Concepciónes_ES
dc.contributor.authorBarberá, Reyeses_ES
dc.contributor.authorAlegría, Amparoes_ES
dc.date.accessioned2017-11-22T13:48:44Z-
dc.date.available2017-11-22T13:48:44Z-
dc.date.issued2017-10-31-
dc.identifier.citationFood Research International 103: 335-344 (2018)es_ES
dc.identifier.issn0963-9969-
dc.identifier.urihttp://hdl.handle.net/10261/157604-
dc.description.abstractFruit pulps from Navel (N) and Cara Cara (CC) oranges, and Clementine mandarin freshly harvested (M) and refrigerated stored (M12) were used to evaluate the cytoprotective effect of their bioaccessible fractions (BF) against H2O2-induced oxidative stress in Caco-2 cells. BF of samples preserved viability vs. H2O2 treated cells, reaching values similar to controls. Lipid peroxidation was reduced to levels of control cells, but M did not reach control values. ROS and mitochondrial membrane potential changes (Δψm) values were reduced compared with H2O2 treated cells, but without achieving control levels. A significant reduction in cell proportions in G1 phase and a significant increase in sub-G1 phase (apoptosis) of cell cycle was shown in H2O2 treated cells, and BF allowed a recovery close to control levels. Thus, BF of samples protect the cells from oxidative stress by preserving cell viability, mitochondrial membrane potential and correct cell cycle progression, and diminishing lipid peroxidation and ROS.es_ES
dc.description.sponsorshipThis study has been funded by the Spanish Ministry of Economy and Competitiveness (MINECO) by the Program Consolider-Ingenio 2010 Fun-C-Food (CSD 2007-00063 project) throughout the Biocitrus consortium. LZ and MJR are members of the CaRed Network (BIO2015-71703-REDT) and EUROCAROTEN COST Action (CA15136).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/BIO2015-71703-REDTes_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectCitrus fruit pulpses_ES
dc.subjectBioactive compoundses_ES
dc.subjectAntioxidantses_ES
dc.subjectIn vitro digestiones_ES
dc.subjectCaco-2 cellses_ES
dc.subjectOxidative stresses_ES
dc.titleProtective effect of bioaccessible fractions of citrus fruit pulps against H2O2-induced oxidative stress in Caco-2 cellses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.foodres.2017.10.066-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.foodres.2017.10.066es_ES
dc.embargo.terms2018-10-31es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commission-
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.pmid29389623-
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