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http://hdl.handle.net/10261/157604
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Cilla, Antonio | es_ES |
dc.contributor.author | Rodrigo, María Jesús | es_ES |
dc.contributor.author | Zacarías, Lorenzo | es_ES |
dc.contributor.author | Ancos, Begoña de | es_ES |
dc.contributor.author | Sánchez-Moreno, Concepción | es_ES |
dc.contributor.author | Barberá, Reyes | es_ES |
dc.contributor.author | Alegría, Amparo | es_ES |
dc.date.accessioned | 2017-11-22T13:48:44Z | - |
dc.date.available | 2017-11-22T13:48:44Z | - |
dc.date.issued | 2017-10-31 | - |
dc.identifier.citation | Food Research International 103: 335-344 (2018) | es_ES |
dc.identifier.issn | 0963-9969 | - |
dc.identifier.uri | http://hdl.handle.net/10261/157604 | - |
dc.description.abstract | Fruit pulps from Navel (N) and Cara Cara (CC) oranges, and Clementine mandarin freshly harvested (M) and refrigerated stored (M12) were used to evaluate the cytoprotective effect of their bioaccessible fractions (BF) against H2O2-induced oxidative stress in Caco-2 cells. BF of samples preserved viability vs. H2O2 treated cells, reaching values similar to controls. Lipid peroxidation was reduced to levels of control cells, but M did not reach control values. ROS and mitochondrial membrane potential changes (Δψm) values were reduced compared with H2O2 treated cells, but without achieving control levels. A significant reduction in cell proportions in G1 phase and a significant increase in sub-G1 phase (apoptosis) of cell cycle was shown in H2O2 treated cells, and BF allowed a recovery close to control levels. Thus, BF of samples protect the cells from oxidative stress by preserving cell viability, mitochondrial membrane potential and correct cell cycle progression, and diminishing lipid peroxidation and ROS. | es_ES |
dc.description.sponsorship | This study has been funded by the Spanish Ministry of Economy and Competitiveness (MINECO) by the Program Consolider-Ingenio 2010 Fun-C-Food (CSD 2007-00063 project) throughout the Biocitrus consortium. LZ and MJR are members of the CaRed Network (BIO2015-71703-REDT) and EUROCAROTEN COST Action (CA15136). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-71703-REDT | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Citrus fruit pulps | es_ES |
dc.subject | Bioactive compounds | es_ES |
dc.subject | Antioxidants | es_ES |
dc.subject | In vitro digestion | es_ES |
dc.subject | Caco-2 cells | es_ES |
dc.subject | Oxidative stress | es_ES |
dc.title | Protective effect of bioaccessible fractions of citrus fruit pulps against H2O2-induced oxidative stress in Caco-2 cells | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.foodres.2017.10.066 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.foodres.2017.10.066 | es_ES |
dc.embargo.terms | 2018-10-31 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 29389623 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IATA) Artículos (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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FRI-2018-Cilla.pdf | Artículo principal | 650,22 kB | Adobe PDF | Visualizar/Abrir |
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