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Título: | Genetic characterization of the ABO blood group in Neandertals |
Autor: | Lalueza-Fox, Carles CSIC ORCID ; Gigli, Elena CSIC; Rasilla, Marco de la; Fortea, Javier; Rosas, Antonio ; Bertranpetit, Jaume CSIC ORCID ; Krause, Johannes | Palabras clave: | ABO blood group system Genetic polymorphism ABO gene Alleles Neandertals Apes Evolution |
Fecha de publicación: | 24-dic-2008 | Editor: | BioMed Central | Citación: | BMC Evolutionary Biology 2008, 8:342 | Resumen: | [Background] The high polymorphism rate in the human ABO blood group gene seems to be related to susceptibility to different pathogens. It has been estimated that all
genetic variation underlying the human ABO alleles appeared along the human lineage,
after the divergence from the chimpanzee lineage. A paleogenetic analysis of the ABO
blood group gene in Neandertals allows us to directly test for the presence of the ABO alleles in these extinct humans. [Results] We have analysed two male Neandertals that were retrieved under controlled conditions at the El Sidrón site in Asturias (Spain) and that appeared to be almost free of modern human DNA contamination. We find a human specific diagnostic deletion for blood group O (O01 haplotype) in both Neandertal individuals. [Conclusions] These results suggest that the genetic change responsible for the O blood group in humans predates the human and Neandertal divergence. A potential selective event associated with the emergence of the O allele may have therefore occurred after humans separated from their common ancestor with chimpanzees and before the human-Neandertal population divergence. |
Descripción: | 20 pages, 1 table.-- Supplementary data file available (16 pages): Clone sequences generated for the ABO blood group gene and mtDNA fragments in Neandertals. The provisional attached PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF version will be made available soon. |
Versión del editor: | http://dx.doi.org/10.1186/1471-2148-8-342 | URI: | http://hdl.handle.net/10261/9389 | DOI: | 10.1186/1471-2148-8-342 | ISSN: | 1471-2148 |
Aparece en las colecciones: | (MNCN) Artículos (IBE) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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Genetic_characterization.pdf | Main text | 149,66 kB | Adobe PDF | Visualizar/Abrir |
Genetic_characterization_supp1.doc | Additional file | 333 kB | Microsoft Word | Visualizar/Abrir |
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