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http://hdl.handle.net/10261/88078
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gallego, Carme | - |
dc.contributor.author | Casellas, Rafael | - |
dc.date.accessioned | 2013-12-03T11:13:20Z | - |
dc.date.available | 2013-12-03T11:13:20Z | - |
dc.date.issued | 2012 | - |
dc.identifier | issn: 0006-4971 | - |
dc.identifier | e-issn: 1528-0020 | - |
dc.identifier.citation | Blood 120(6): 1254-1261 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/88078 | - |
dc.description.abstract | Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized by cutaneous fibrofolliculomas, pulmonary cysts, and kidney malignancies. Affected individuals carry germ line mutations in folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney tumors by second-hit mutations. Similar to other factors implicated in kidney cancer, FLCN has been shown to modulate activation of mammalian target of rapamycin (mTOR). However, its precise in vivo function is largely unknown because germ line deletion of Flcn results in early embryonic lethality in animal models. Here, we describe mice deficient in the newly characterized folliculin-interacting protein 1 (Fnip1). In contrast to Flcn, Fnip1-/- mice develop normally, are not susceptible to kidney neoplasia, but display a striking pro-B cell block that is entirely independent of mTOR activity.We show that this developmental arrest results from rapid caspase-induced pre-B cell death, and that a Bcl2 transgene reconstitutes mature B-cell populations, respectively.We also demonstrate that conditional deletion of Flcn recapitulates the pro-B cell arrest of Fnip1-/- mice. Our studies thus demonstrate that the FLCN-FNIP complex deregulated in BHD syndrome is absolutely required for B-cell differentiation, and that it functions through both mTOR-dependent and independent pathways. | - |
dc.description.sponsorship | This work was supported in part by the Intramural Research Program of NIAMS and NCI, Center for Cancer Research, National Institutes of Health (NIH). This project was funded in part with federal funds from the NCI, NIH, under contract no. HHSN261200800001E. | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Hematology | - |
dc.rights | closedAccess | - |
dc.title | The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1182/blood-2012-02-410407 | - |
dc.date.updated | 2013-12-03T11:13:23Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 22709692 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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