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Título: | RTK signaling modulates the Dorsal gradient |
Autor: | Andreu, María José CSIC; Kim, Yoosik; Jiménez, Gerardo CSIC ORCID ; Shvartsman, Stanislav Y.; Paroush, Ze'ev | Palabras clave: | RTK signaling Negative feedback Gene regulation Drosophila Dorsal |
Fecha de publicación: | 2012 | Editor: | Company of Biologists | Citación: | Development 139(16): 3032-3039 (2012) | Resumen: | The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates or represses numerous target genes in a region-specific manner. Here, we demonstrate that signaling by receptor tyrosine kinases (RTK) reduces nuclear levels and transcriptional activity of Dl, both at the poles and in the mid-body of the embryo. These effects depend on wntD, which encodes a Dl antagonist belonging to the Wingless/Wnt family of secreted factors. Specifically, we show that, via relief of Groucho- and Capicua-mediated repression, the Torso and EGFR RTK pathways induce expression of WntD, which in turn limits Dl nuclear localization at the poles and along the DV axis. Furthermore, this RTK-dependent control of Dl is important for restricting expression of its targets in both contexts. Thus, our results reveal a new mechanism of crosstalk, whereby RTK signals modulate the spatial distribution and activity of a developmental morphogen in vivo. 2012. © Published by The Company of Biologists Ltd. | URI: | http://hdl.handle.net/10261/87986 | DOI: | 10.1242/dev.075812 | Identificadores: | doi: 10.1242/dev.075812 issn: 0950-1991 e-issn: 1477-9129 |
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