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Título: | Sensorineural hearing loss in insulin-like growth factor I-null mice: A new model of human deafness |
Autor: | Cediel, Rafael CSIC; Riquelme, Raquel; Contreras, Julio CSIC; Varela-Nieto, Isabel CSIC ORCID | Fecha de publicación: | 2006 | Editor: | Wiley-Blackwell | Citación: | European Journal of Neuroscience 23(2): 587-590 (2006) | Resumen: | It has been reported that mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic hearing loss. To study the precise role of IGF-I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF-I deficiency. We show here that homozygous Igf-1-/- mice present an all-frequency involved bilateral sensorineural hearing loss. Igf-1-/- mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf-1-/- mice. These results support the use of the Igf-1-/- mouse as a new model for the study of human syndromic deafness. © The Authors (2006). | URI: | http://hdl.handle.net/10261/81374 | DOI: | 10.1111/j.1460-9568.2005.04584.x | Identificadores: | doi: 10.1111/j.1460-9568.2005.04584.x issn: 0953-816X e-issn: 1460-9568 |
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