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Sensorineural hearing loss in insulin-like growth factor I-null mice: A new model of human deafness

AuthorsCediel, Rafael ; Riquelme, Raquel; Contreras, Julio ; Varela-Nieto, Isabel
Issue Date2006
CitationEuropean Journal of Neuroscience 23(2): 587-590 (2006)
AbstractIt has been reported that mutations in the gene encoding human insulin-like growth factor-I (IGF-I) cause syndromic hearing loss. To study the precise role of IGF-I in auditory function and to hypothesize the possible morphological and electrophysiological changes that may occur in the human inner ear, we have analysed the auditory brainstem response in a mouse model of IGF-I deficiency. We show here that homozygous Igf-1-/- mice present an all-frequency involved bilateral sensorineural hearing loss. Igf-1-/- mice also present a delayed response to acoustic stimuli; this increases along the auditory pathway, indicating a contribution of the central nervous system to the hearing loss in Igf-1-/- mice. These results support the use of the Igf-1-/- mouse as a new model for the study of human syndromic deafness. © The Authors (2006).
Identifiersdoi: 10.1111/j.1460-9568.2005.04584.x
issn: 0953-816X
e-issn: 1460-9568
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