Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/79361
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | 1,25-dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells |
Autor: | González-Sancho, José Manuel CSIC ORCID; Álvarez-Dolado, Manuel CSIC ORCID CVN; Muñoz Terol, Alberto CSIC ORCID | Fecha de publicación: | 1998 | Editor: | Elsevier | Citación: | FEBS Letters 426(2): 225-228 (1998) | Resumen: | Tenascin-C is an extracellular matrix protein with growth-, invasion- and angiogenesis-promoting activities. Tenasein-C is upregulated in breast carcinoma and stromal cells, and in many other cell types during tumorigenesis. We demonstrate that tenascin-C RNA expression is inhibited by 1,25-dihydroxyvitamin D3 (1,25-D3) in a variety of mouse and human mammary epithelial cell lines exhibiting normal or malignant phenotype. In EpH4 cells, the inhibition is maximum 24 h after 1,25-D3 treatment and correlates with a dose-dependent reduction in the synthesis of tenascin-C protein. Furthermore, 1,25-D3 also abolishes the induction of tenascin-C by serum or the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate. The inhibition of tenascin-C expression may be relevant for the anticancer activity of 1,25- D3. | URI: | http://hdl.handle.net/10261/79361 | DOI: | 10.1016/S0014-5793(98)00348-2 | Identificadores: | doi: 10.1016/S0014-5793(98)00348-2 issn: 0014-5793 e-issn: 1873-3468 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
44
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
34
checked on 23-feb-2024
Page view(s)
409
checked on 05-may-2024
Download(s)
104
checked on 05-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.