Nanostructured Electrodes for In Vitro Electrical Stimulation Platforms

Abstract

We have developed a platform that combines nanostructured Pt electrodes with a microgrooved-compartmentalized cell culture module, for electrical stimulation of neural cells. We demonstrated that nanostructuration significantly improves electrochemical properties of the bioelectrodes, including charge storage capacity. Moreover, nanostructuration has positive effect on conserving the delivered signal. We also, established a methodology for simulating stimualtion conditions before experimental work. Future work will be focused on culturing neural cells in this platform, to expand their axonal compartment within the grooves, and testing the effect of electrical stimulation on growth and survival of the axons.