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http://hdl.handle.net/10261/348741
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dc.contributor.author | Morente-López, Miriam | es_ES |
dc.contributor.author | Mato-Basalo, Rocío | es_ES |
dc.contributor.author | Lucio-Gallego, Sergio | es_ES |
dc.contributor.author | Gil, Concha | es_ES |
dc.contributor.author | Carrera, Mónica | es_ES |
dc.contributor.author | Fafián-Labora, Juan | es_ES |
dc.contributor.author | Mateos, Jesús | es_ES |
dc.contributor.author | Arufe, María C. | es_ES |
dc.date.accessioned | 2024-02-29T09:07:00Z | - |
dc.date.available | 2024-02-29T09:07:00Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Stem Cell Research and Therapy 14: 383 (2023) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/348741 | - |
dc.description | 15 pages, 6 figures, 1 table.-- This article is licensed under a Creative Commons Attribution 4.0 International License | es_ES |
dc.description.abstract | [Background] A challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the senescence-associated secretory phenotype (SASP) which characterizes senescent cells and contributes to driving inflammation. [Methods] Mesenchymal stem cells (MSC) from human umbilical cord stroma were stable modified using lentivirus transduction to inhibit miR-21-5p and shotgun proteomic analysis was performed in the MSC-derived extracellular vesicles (EV) to check the effect of miR-21 inhibition in their protein cargo. Besides, we studied the paracrine effect of those modified extracellular vesicles and also their effect on SASP. [Results] Syndecan-1 (SDC1) was the most decreased protein in MSC-miR21−-derived EV, and it was involved in inflammation and EV production. MSC-miR21−-derived EV were found to produce a statistically significant inhibitory effect on SASP and inflammaging markers expression in receptor cells, and in the opposite way, these receptor cells increased their SASP and inflammaging expression statistically significantly when treated with MSC-miR-21+-derived EV. [Conclusion] This work demonstrates the importance of miR-21 in inflammaging and its role in SASP through SDC1 | es_ES |
dc.description.sponsorship | J.A.F-L was funded by Xunta de Galicia, Grants Number (ED481D-2021-020, 11_IN858A_2021_114114 and ED431F 2023/030), the Ministerio de Ciencia e Innovación (RYC2021-032567-I) and the InTalent program from UDC-Inditex for the research grant. J.M. acknowledge the support of Xunta de Galicia (GAIN) by Talent Senior research grant (11_IN858A_2021_1141142). M.C.A. has been funded by Instituto de Salud Carlos III through the project “PI20/00497.” Co-funded by European Regional Development Fund “A way to make Europe.” | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.relation.isbasedon | The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.1186/s13287-023-03613-z | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Mesenchymal stem cells (MSC) | es_ES |
dc.subject | Extracellular vesicles (EV) | es_ES |
dc.subject | miR-21-5p (miR-21) | es_ES |
dc.subject | Syndecan-1 (SDC1) | es_ES |
dc.subject | Senescence-associated secretory phenotype (SASP) | es_ES |
dc.subject | Inflammaging | es_ES |
dc.title | Effect of miR‑21 in mesenchymal stem cells‑derived extracellular vesicles behavior | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1186/s13287-023-03613-z | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/s13287-023-03613-z | es_ES |
dc.identifier.e-issn | 1757-6512 | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Xunta de Galicia | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Universidad de La Coruña | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010801 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
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Effect_mir21_mesenchymal_OA_2023.pdf | 5,29 MB | Adobe PDF | Visualizar/Abrir | |
SupStem_cell_2023.zip | 6,22 MB | zip | Visualizar/Abrir |
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