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Título: | The RNA-binding protein PTB exerts translational control on 3′-untranslated region of the mRNA for the ATP synthase β-subunit |
Autor: | Reyes, Raquel CSIC ORCID; Izquierdo, José M. CSIC ORCID | Palabras clave: | PTB TIA-1 TIAR β-F1-ATPase mRNA Gene expression control |
Fecha de publicación: | 15-jun-2007 | Editor: | Elsevier | Citación: | Biochemical and Biophysical Research Communications 357(4): 1107-1112 (2007) | Resumen: | We have recently reported that RNA-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1 related protein), and HuR (Hu antigen R) modulate the expression of the ATP synthase β-subunit mRNA (β-F1-ATPase mRNA) [J.M. Izquierdo, Control of the ATP synthase β subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR, Biochem. Biophys. Res. Commun. 348 (2006) 703–711]. Here we found that PTB (Polypyrimidine Tract–Binding Protein) is a novel member of the ribonucleoprotein complex that interacts with the β-F1-ATPase mRNA through an adenosine/uridine (AU)-rich element located to the β-F1-ATPase 3′-untranslated region (β-3′-UTR). Co-expression of GFP from a reporter mRNA quimera containing human β-3′-UTR and recombinant PTB in HeLa cells increased the amount of GFP protein. Interestingly, this effect is not due to increased steady-state levels of GFP-β-3′-UTR mRNA. Taken together, these results suggest that PTB regulates post-transcriptional expression of the β-F1-ATPase mRNA at the translational level. | Versión del editor: | https://doi.org/10.1016/j.bbrc.2007.04.088 | URI: | http://hdl.handle.net/10261/343357 | DOI: | 10.1016/j.bbrc.2007.04.088 | ISSN: | 0006-291X |
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Reyes_Postprint_BBRC_2007.pdf | 4,66 MB | Adobe PDF | Visualizar/Abrir |
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