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http://hdl.handle.net/10261/343357
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Reyes, Raquel | es_ES |
dc.contributor.author | Izquierdo, José M. | es_ES |
dc.date.accessioned | 2024-01-23T13:51:23Z | - |
dc.date.available | 2024-01-23T13:51:23Z | - |
dc.date.issued | 2007-06-15 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications 357(4): 1107-1112 (2007) | es_ES |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10261/343357 | - |
dc.description.abstract | We have recently reported that RNA-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1 related protein), and HuR (Hu antigen R) modulate the expression of the ATP synthase β-subunit mRNA (β-F1-ATPase mRNA) [J.M. Izquierdo, Control of the ATP synthase β subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR, Biochem. Biophys. Res. Commun. 348 (2006) 703–711]. Here we found that PTB (Polypyrimidine Tract–Binding Protein) is a novel member of the ribonucleoprotein complex that interacts with the β-F1-ATPase mRNA through an adenosine/uridine (AU)-rich element located to the β-F1-ATPase 3′-untranslated region (β-3′-UTR). Co-expression of GFP from a reporter mRNA quimera containing human β-3′-UTR and recombinant PTB in HeLa cells increased the amount of GFP protein. Interestingly, this effect is not due to increased steady-state levels of GFP-β-3′-UTR mRNA. Taken together, these results suggest that PTB regulates post-transcriptional expression of the β-F1-ATPase mRNA at the translational level. | es_ES |
dc.description.sponsorship | This work was supported by a grant from the Fondo de Investigaciones Sanitarias (PI051605), Spain. R.R. is a recipient of a postgraduate fellowship from the Universidad Autónoma de Madrid. An institutional grant to the CBMSO from Fundación Ramón Areces is acknowleged. | es_ES |
dc.format | application/pdf | - |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | es_ES |
dc.subject | PTB | es_ES |
dc.subject | TIA-1 | es_ES |
dc.subject | TIAR | es_ES |
dc.subject | β-F1-ATPase mRNA | es_ES |
dc.subject | Gene expression control | es_ES |
dc.title | The RNA-binding protein PTB exerts translational control on 3′-untranslated region of the mRNA for the ATP synthase β-subunit | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.bbrc.2007.04.088 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.bbrc.2007.04.088 | es_ES |
dc.contributor.funder | Universidad Autónoma de Madrid | es_ES |
dc.contributor.funder | Fundación Ramón Areces | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004593 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
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Reyes_Postprint_BBRC_2007.pdf | 4,66 MB | Adobe PDF | Visualizar/Abrir |
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