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Título: | The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19 |
Autor: | Martin-Castaño, Benita; Diez-Echave, Patricia; García-García, Jorge; Hidalgo-García, Laura; Ruiz-Malagon, Antonio Jesús; Molina-Tijeras, José Alberto; Rodríguez-Sojo, María Jesús; Redruello-Romero, Anaïs; Martínez-Zaldívar, Margarita; Mota, Emilio; Cobo, Fernando; Díaz-Villamarin, Xando; Fernández-Varón, Emilio; Alvarez-Estevez, Marta; García, Federico; Morales-García, Concepción; Merlos, Silvia; Garcia-Flores, Paula; Colmenero-Ruiz, Manuel; Ruiz-Sancho, Andrés; Nuñez, María; Rodríguez-Cabezas, María Elena; Carazo, Ángel; Martín, Javier; Morón, Rocío; Rodríguez, Alba; Galvez, Julio | Palabras clave: | COVID-19 Gut microbiota Nasopharyngeal microbiota SARS-CoV-2 Severity |
Fecha de publicación: | 13-ene-2024 | Editor: | BioRxiv | Citación: | Martin-Castaño, Benita; Diez-Echave, Patricia; García-García, Jorge; Hidalgo-García; Ruiz-Malagon, Antonio Jesús; Molina-Tijeras, José Alberto; Rodríguez-Sojo, María Jesús; Redruello-Romero, Anaïs; Martínez-Zaldívar, Margarita; Mota, Emilio; Cobo, Fernando; Díaz-Villamarin, Xando; Fernández-Varón, Emilio; Alvarez-Estevez, Marta; García, Federico; Morales-García, Concepción; Merlos, Silvia; Garcia-Flores, Paula; Colmenero-Ruiz, Manuel; Ruiz-Sancho, Andrés; Nuñez, María; Rodríguez-Cabezas, María Elena; Carazo, Ángel; Martín, Javier; Morón, Rocío; Rodríguez, Alba; Galvez, Julio; 2024; The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19; BioRxiv; https://doi.org/10.1101/2024.01.11.575201 | Resumen: | Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity but no specific determinants of infection outcome have been identified yet, maybe due the complex pathogenic mechanisms. The microbiota could play a key role in the infection and in the progression and outcome of the disease. Hence, SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. Methods: To identify new prognostic markers for the disease, a multicenter prospective observational cohort study was carried out in COVID-19 patients that were divided in three cohorts according to their symptomatology: mild (n=24), moderate (n=51) and severe/critical (n=31). Faecal and nasopharyngeal samples were taken and the microbiota was analysed. Results: Microbiota composition could be associated with the severity of the symptoms and the linear discriminant analysis identified the genera Mycoplasma and Prevotella as severity biomarkers in nasopharyngeal samples, and Allistipes, Enterococcus and Escherichia in faecal samples. Moreover, M. salivarium was defined as a unique microorganism in COVID-19 patients' nasopharyngeal microbiota while P. bivia and P. timonensis were defined in faecal microbiota. A connection between faecal and nasopharyngeal microbiota in COVID-19 patients was also identified as a strong positive correlation between P. timonensis (faeces) towards P. dentalis and M. salivarium(nasopharyngeal) was found in critically ill patients. Conclusions: This ratio could be used as a novel prognostic biomarker for severe COVID-19 patients. | Versión del editor: | https://doi.org/10.1101/2024.01.11.575201 | URI: | http://hdl.handle.net/10261/342413 | DOI: | 10.1101/2024.01.11.575201 |
Aparece en las colecciones: | (IPBLN) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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