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Título: | Synthesis of 2'-O-Methyl/2'-O-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies |
Autor: | Martín-Nieves, Virginia; Menéndez-Méndez, Luis Miguel; Fàbrega, Carme CSIC ORCID; Fernández, Susana; Sanghvi, Yogesh S.; Ferrero, Miguel; Eritja Casadellà, Ramón CSIC ORCID | Palabras clave: | Nucleosides Antiviral G-quadruplexes 2′-O-Methyl/2′-O-MOE-L-Nucleoside Derivatives L-oligonucleotides |
Fecha de publicación: | 28-nov-2023 | Editor: | American Chemical Society | Citación: | ACS Omega 8 (47): 44893–44904 (2023) | Resumen: | Nucleosides and their analogues constitute an important family of molecules with potential antiviral and antiproliferative activity. The enantiomers of natural nucleosides, l-nucleoside derivatives, which have comparable biological activity but more favorable toxicological properties and greater metabolic stability than d-nucleosides, have emerged as a new class of therapeutic agents. Furthermore, l-nucleosides can be used as a building block to prepare l-oligonucleotides, which have identical physical properties in terms of solubility, hybridization kinetics, and duplex thermal stability as d-oligonucleotides but completely orthogonal in nature. Consequently, they are resistant to nuclease degradation, nontoxic, and immunologically passive, which are desirable properties for biomedical applications. Herein, we describe the synthesis of several 2'-O-methyl/2'-O-MOE-l-nucleoside pyrimidine derivatives and their incorporation into G-rich oligonucleotides. Finally, we evaluated the stability and resistance against nucleases of these new G-quadruplexes, demonstrating the potential of the l-nucleosides described in this work in providing enhanced nuclease resistance with a minimal impact in the nucleic acid structural properties. | Versión del editor: | https://doi.org/10.1021/acsomega.3c06231 | URI: | http://hdl.handle.net/10261/340389 | DOI: | 10.1021/acsomega.3c06231 |
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martín-nieves-et-al-2023-synthesis-of-2-o-methyl-2-o-moe-l-nucleoside-derivatives-and-their-applications-preparation-of.pdf | Artículo principal | 2,72 MB | Adobe PDF | Visualizar/Abrir |
ao3c06231_si_001.pdf | Material suplementario | 4,5 MB | Adobe PDF | Visualizar/Abrir |
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