Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/335008
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | New insights on the mechanisms of drug release from highly concentrated emulsions |
Autor: | Llinàs, Meritxell CSIC; Calderó, Gabriela CSIC ORCID; García-Celma, M. J. CSIC ORCID; Patti, Alessandro; Solans, Conxita CSIC ORCID | Palabras clave: | Controlled release Diffusion coefficient PH dependent solubility Release mechanism W/O highly concentrated emulsion |
Fecha de publicación: | 15-mar-2013 | Editor: | Elsevier | Citación: | Journal of Colloid and Interface Science 394: 337-345 (2013) | Resumen: | High kinetic stability water-in-oil high internal phase ratio emulsions (W/O-HIPREs) have been obtained in a 0.5% Theophylline (TP) aqueous solution/Cremophor WO7/liquid paraffin system at 25 °C. The release of TP has been studied from HIPREs with pH values of the dispersed phase ranging between 2 and 12. Although the release from aqueous solutions was not influenced by pH, the release from HIPREs depended strongly on the pH of the dispersed phase. Increasing the solubility of TP in the dispersed phase, its apparent diffusion coefficient decreased over two orders of magnitude. Two different physico-chemical models have been applied to describe the diffusion of TP, showing an excellent agreement with experiments and confirming the role of the structure of the emulsions and the solubility of the drug. It has been shown that only non-ionized species are able to cross the interfacial film. Therefore, at pH>pKa diffusion is limited by the concentration of non-ionized species inside the emulsion droplets, while at pH<pKa diffusion is determined by the interfacial film. This demonstrates that solubility of the diffusing molecule can have a higher effect on release from HIPREs than the interfacial film properties. | Versión del editor: | https://doi.org/10.1016/j.jcis.2012.11.025 | URI: | http://hdl.handle.net/10261/335008 | DOI: | 10.1016/j.jcis.2012.11.025 | ISSN: | 0021-9797 | E-ISSN: | 1095-7103 |
Aparece en las colecciones: | (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Acceso_restringido.pdf | 108,79 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 23-abr-2024
SCOPUSTM
Citations
9
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 22-feb-2024
Page view(s)
23
checked on 27-abr-2024
Download(s)
8
checked on 27-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.