Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/331129
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Additional file 7 of Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease |
Autor: | Salvadores, Natalia; Moreno-González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas-Gómez, Laura; Escandón, Marcela; Jiménez, Sebastián; Vitorica, Javier CSIC ORCID; Gutiérrez, Antonia; Soto, Claudio; Court, Felipe A. | Palabras clave: | Alzheimer’s disease Amyloid-β oligomers Necroptosis Microglia Neurodegeneration Neuroprotection |
Fecha de publicación: | 10-mar-2022 | Editor: | Figshare | Citación: | Salvadores, Natalia; Moreno-González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas-Gómez, Laura; Escandón, Marcela; Jiménez, Sebastián; Vitorica, Javier; Gutiérrez, Antonia; Soto, Claudio; Court, Felipe A.; 2022; Additional file 7 of Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease [Dataset]; Figshare; https://doi.org/10.6084/m9.figshare.19336250.v1 | Resumen: | Additional file 7: Fig. S7. Aβo neurotoxicity is worsened when microglial cells are present. (A) To characterize Aβo, a negative stain with 1% uranyl acetate was performed followed by electron microscopy analysis. Arrows indicate small oligomeric structures (scale bar, 200 nm). (B, C) Representative images and quantitative analysis of neurons treated as indicated, immunostained with anti-acetylated tubulin antibody (scale bar, 100 μm). (D, E) Representative micrographs and quantitative measurement of neurons and neuron/microglia cocultures treated as indicated, immunolabeled with anti-acetylated tubulin and anti-Iba1 antibodies as specified in the images (scale bar, 100 μm in the middle panel; 50 μm in the right panel). Each experiment was performed at least three independent times, with three replicates per condition each time. The data are presented as mean ± S.E.M. and were analyzed by one-way ANOVA followed by Bonferroni post-test. *p < 0.05; **p < 0.01; ****p < 0.0001. | Versión del editor: | https://doi.org/10.6084/m9.figshare.19336250.v1 | URI: | http://hdl.handle.net/10261/331129 | DOI: | 10.6084/m9.figshare.19336250.v1 | Referencias: | Salvadores, Natalia; Moreno-González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas-Gómez, Laura; Escandón, Marcela; Jiménez, Sebastián; Vitorica, Javier; Gutiérrez, Antonia; Soto, Claudio; Court, Felipe A. Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease. https://doi.org/10.1186/s40478-022-01332-9 . http://hdl.handle.net/10261/295796 |
Aparece en las colecciones: | (IBIS) Conjuntos de datos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Additional-file-7-Aβ-oligomers-trigger.tif | 2,62 MB | TIFF | Visualizar/Abrir | |
README.txt | 3,64 kB | Text | Visualizar/Abrir |
CORE Recommender
Page view(s)
50
checked on 01-may-2024
Download(s)
4
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons